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PET tracers

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PET tracers

¹⁸F-FDG · Fluorodeoxyglucose

Glucose analog labeled with fluorine-18, taken up by cells with increased glucose metabolism. Reference PET tracer in oncology, cardiology and infectious diseases.

⁶⁸Ga-PSMA-11

Peptide ligand targeting prostate-specific membrane antigen (PSMA). Reference for prostate cancer assessment (biochemical recurrence, high-risk staging).

⁶⁸Ga-DOTATATE

Somatostatin analog binding with high affinity to SSTR2 receptor. Reference for imaging well-differentiated neuroendocrine tumors (NETs).

¹⁸F-FET · Fluoroethyl-tyrosine

Tyrosine analog labeled with fluorine-18, taken up by the amino acid transport system (LAT). Reference for imaging primary brain tumors and recurrence/radionecrosis differential.

¹⁸F-Fluorocholine

Choline analog labeled with fluorine-18, taken up by cells with increased phospholipid metabolism. Main indications: prostate cancer (recurrence) and parathyroid adenomas.

⁶⁸Ga-FAPI-46

Fibroblast Activation Protein (FAP) inhibitor, expressed on activated fibroblasts of tumor stroma. Emerging pan-oncological tracer in clinical evaluation.

¹⁸F-PSMA-1007

PSMA ligand labeled with fluorine-18 with very low urinary excretion (major advantage for pelvis). European reference for prostate cancer assessment.

¹⁸F-DCFPyL · Piflufolastat (Pylarify®)

PSMA ligand labeled with fluorine-18, first PSMA radiotracer approved by FDA. Assessment of metastatic or recurrent prostate cancer.

¹⁸F-FDOPA · Fluoro-DOPA

Dopamine precursor labeled with fluorine-18. Imaging of dopaminergic system (Parkinson), neuroendocrine tumors and gliomas.

¹⁸F-Fluoride (NaF) · Sodium fluoride

Bone tracer by incorporation in hydroxyapatite. Detection of bone metastases and skeletal pathologies. Pre-FDG reference in osteology.

¹⁸F-Flortaucipir (Tauvid®)

Tau protein (PHF) deposit tracer labeled with fluorine-18. Imaging of Alzheimer's disease and tauopathies. EMA approval 2024.

¹⁸F-Amyloid (Florbetaben/Flutemetamol/Florbetapir)

Family of 3 β-amyloid plaque tracers with fluorine-18 (Neuraceq, Vizamyl, Amyvid). Diagnostic imaging of Alzheimer's disease.

⁶⁸Ga-DOTATOC

Somatostatin analog (DOTA-D-Phe¹-Tyr³-octreotide) with high affinity for SSTR2. Alternative to DOTATATE for NET imaging.

¹¹C-Methionine

Essential amino acid labeled with carbon-11. Imaging of primary brain tumors and gliomas. Historical reference for amino acids in PET.

¹¹C-Choline

Choline labeled with carbon-11. Imaging of cells with high membrane metabolism. Hospital alternative to ¹⁸F-choline.

¹³N-Ammonia

Ammonia labeled with nitrogen-13. PET myocardial perfusion imaging. Reference for absolute coronary blood flow quantification.

¹⁵O-H₂O · Labeled water

Water labeled with oxygen-15. Gold standard reference for absolute cerebral and myocardial blood flow quantification. Free diffusion.

⁸⁹Zr-Trastuzumab

Trastuzumab antibody (anti-HER2) labeled with zirconium-89. ImmunoPET for HER2+ breast cancer assessment. Long T½ (78h) adapted to antibody pharmacokinetics.

Reference content from the original site. Dates and statuses reflect the sources; no new scientific verification has been performed.

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