{"overview":{"css":"\n :host{\n --bg:#F5F3EF;\n --surface:#fff;\n --text:#13213A;\n --muted:#5B7489;\n --line:#D5E5F0;\n --line2:#E0DDD7;\n --navy:#0D1B2A;\n --navy2:#0D3B5C;\n --blue:#1565C0;\n --blue2:#42A5F5;\n --blueSoft:#EAF3FA;\n --gold:#C89B3C;\n --green:#1B7F4A;\n --orange:#E65100;\n --purple:#6A1B9A;\n --red:#C62828;\n --shadow:0 10px 26px rgba(13,27,42,.08);\n --max:1400px;\n }\n\n *{box-sizing:border-box}\n\n .source-body{\n margin:0;\n background:var(--bg);\n color:var(--text);\n font-family:'DM Sans', Inter, system-ui, -apple-system, BlinkMacSystemFont, \"Segoe UI\", sans-serif;\n }\n\n a{text-decoration:none;color:inherit}\n button,select,input{font:inherit}\n\n /* TOPBAR MOCKUP */\n .mock-topbar{\n height:56px;\n background:#fff;\n border-bottom:1px solid var(--line2);\n display:flex;\n align-items:center;\n justify-content:space-between;\n padding:0 24px;\n position:sticky;\n top:0;\n z-index:30;\n }\n\n .mock-brand{\n font-family:Georgia,serif;\n font-size:23px;\n font-weight:700;\n color:var(--navy2);\n }\n\n .mock-brand small{\n font-family:Inter,sans-serif;\n font-size:12px;\n color:#6B6B6B;\n margin-left:8px;\n font-weight:500;\n }\n\n .mock-actions{\n display:flex;\n gap:8px;\n align-items:center;\n font-size:12px;\n color:var(--navy2);\n }\n\n .mock-action{\n background:#fff;\n border:1px solid var(--line);\n border-radius:8px;\n padding:7px 10px;\n font-weight:700;\n }\n\n /* MAIN LAYOUT MOCKUP */\n .mock-shell{\n display:block;\n }\n\n .mock-side{\n background:#EAF3FA;\n border-right:1px solid var(--line);\n min-height:calc(100vh - 56px);\n padding:12px 8px;\n display:flex;\n flex-direction:column;\n gap:8px;\n position:sticky;\n top:56px;\n align-self:start;\n }\n\n .side-logo,\n .side-item{\n background:#fff;\n border:1px solid var(--line);\n border-radius:12px;\n min-height:72px;\n display:flex;\n flex-direction:column;\n align-items:center;\n justify-content:center;\n text-align:center;\n color:var(--navy2);\n font-size:11px;\n font-weight:700;\n line-height:1.15;\n box-shadow:0 2px 6px rgba(0,0,0,.04);\n }\n\n .side-logo{\n min-height:86px;\n font-family:Georgia,serif;\n }\n\n .side-icon{\n font-size:20px;\n margin-bottom:5px;\n }\n\n .side-logo .side-icon{\n font-size:32px;\n }\n\n .side-item.active{\n background:#CDE4F7;\n border-color:#9EC2DC;\n color:var(--navy);\n }\n\n /* HEADER */\n .thera-header{\n min-height:150px;\n background:\n linear-gradient(90deg,rgba(8,20,52,.72),rgba(8,20,52,.10)),\n linear-gradient(135deg,#0D47A1,#42A5F5);\n display:flex;\n align-items:center;\n color:#fff;\n padding:24px 0;\n position:relative;\n overflow:hidden;\n }\n\n .thera-header:after{\n content:'';\n position:absolute;\n right:0;\n top:0;\n bottom:0;\n width:340px;\n background:\n radial-gradient(circle at 75% 35%,rgba(255,255,255,.45),transparent 9%),\n radial-gradient(circle at 55% 60%,rgba(255,215,137,.35),transparent 8%),\n radial-gradient(circle at 90% 75%,rgba(66,165,245,.6),transparent 11%);\n opacity:.72;\n }\n\n .thera-header-inner{\n width:min(var(--max),calc(100% - 48px));\n margin:0 auto;\n position:relative;\n z-index:1;\n display:flex;\n align-items:center;\n justify-content:space-between;\n gap:32px;\n flex-wrap:wrap;\n }\n\n .thera-header-left{flex:1;min-width:280px}\n\n .thera-header-right{\n text-align:right;\n flex-shrink:0;\n max-width:380px;\n }\n .thera-header-right a{\n display:inline-flex;\n flex-direction:column;\n align-items:flex-end;\n gap:4px;\n color:#fff;\n transition:transform .15s;\n text-decoration:none;\n }\n .thera-header-right a:hover{transform:translateX(-3px)}\n .thera-header-right .right-label{\n font-size:11px;\n text-transform:uppercase;\n letter-spacing:1.5px;\n opacity:.7;\n font-weight:600;\n }\n .thera-header-right .right-title{\n font-family:Georgia,serif;\n font-size:1.05rem;\n line-height:1.3;\n color:#fff;\n font-weight:500;\n }\n .thera-header-right .right-title::after{\n content:' →';\n font-family:inherit;\n color:var(--gold);\n margin-left:6px;\n }\n\n @media (max-width:768px){\n .thera-header-right{text-align:left;max-width:100%}\n .thera-header-right a{align-items:flex-start}\n }\n\n .thera-header h1{\n font-family:Georgia,serif;\n font-size:clamp(1.7rem,3vw,2.35rem);\n margin:0 0 6px;\n color:white;\n text-shadow:0 2px 8px rgba(0,0,0,.32);\n }\n\n .thera-header p{\n margin:0;\n color:rgba(255,255,255,.9);\n font-size:.95rem;\n }\n\n .page{\n width:min(var(--max),calc(100% - 48px));\n margin:22px auto 56px;\n }\n\n .top-note{\n border-left:4px solid var(--gold);\n background:#FFF8EA;\n border-radius:12px;\n padding:13px 16px;\n color:#5A4625;\n font-size:13px;\n line-height:1.55;\n margin-bottom:16px;\n }\n\n .top-note strong{\n color:#3f2f12;\n }\n\n /* KPI */\n .kpis{\n display:grid;\n grid-template-columns:repeat(4,1fr);\n gap:12px;\n margin-bottom:16px;\n }\n\n .kpi{\n background:#fff;\n border:1px solid var(--line2);\n border-radius:16px;\n padding:16px;\n box-shadow:0 6px 18px rgba(13,27,42,.05);\n display:grid;\n grid-template-columns:46px 1fr;\n gap:12px;\n align-items:center;\n }\n\n .kpi-icon{\n width:46px;\n height:46px;\n border-radius:50%;\n display:grid;\n place-items:center;\n background:var(--blueSoft);\n font-size:22px;\n }\n\n .kpi.green .kpi-icon{background:#EAF8EF}\n .kpi.orange .kpi-icon{background:#FFF3E0}\n .kpi.purple .kpi-icon{background:#F4EAFB}\n\n .kpi .label{\n font-size:12px;\n color:var(--navy2);\n font-weight:900;\n margin-bottom:4px;\n line-height:1.2;\n }\n\n .kpi .num{\n font-family:Georgia,serif;\n font-size:26px;\n color:var(--navy);\n font-weight:900;\n line-height:1;\n }\n\n .kpi .sub{\n font-size:11px;\n color:var(--muted);\n margin-top:4px;\n }\n\n /* INTRO */\n .intro{\n background:#fff;\n border:1px solid var(--line2);\n border-radius:18px;\n padding:20px 22px;\n margin-bottom:16px;\n box-shadow:0 4px 14px rgba(13,27,42,.04);\n }\n\n .intro h2{\n font-family:Georgia,serif;\n font-size:25px;\n margin:0 0 10px;\n color:var(--navy);\n }\n\n .intro p{\n margin:0;\n color:#324761;\n line-height:1.62;\n font-size:15px;\n max-width:1050px;\n }\n\n /* CONCEPTS — théranostique + RIV */\n .concepts{\n display:grid;\n grid-template-columns:1fr 1fr;\n gap:18px;\n margin-bottom:20px;\n }\n .concept{\n background:#fff;\n border:1px solid var(--line2);\n border-radius:18px;\n padding:24px 26px;\n position:relative;\n box-shadow:0 8px 22px rgba(13,27,42,.05);\n display:flex;\n flex-direction:column;\n gap:14px;\n overflow:hidden;\n }\n .concept::before{\n content:\"\";\n position:absolute;\n top:0; left:0; right:0;\n height:4px;\n background:linear-gradient(90deg, var(--navy2), var(--blue));\n }\n .concept-riv::before{\n background:linear-gradient(90deg, #C2185B, var(--orange));\n }\n .concept-tag{\n display:inline-flex;\n align-items:center;\n gap:8px;\n align-self:flex-start;\n font-size:11px;\n font-weight:700;\n letter-spacing:1.4px;\n text-transform:uppercase;\n color:var(--navy2);\n background:var(--blueSoft);\n padding:6px 12px;\n border-radius:999px;\n }\n .concept-riv .concept-tag{\n color:#AD1457;\n background:#FFEBEE;\n }\n .concept-dot{\n width:7px;\n height:7px;\n border-radius:50%;\n background:var(--blue);\n box-shadow:0 0 0 3px rgba(21,101,192,.18);\n }\n .concept-riv .concept-dot{\n background:#C2185B;\n box-shadow:0 0 0 3px rgba(194,24,91,.18);\n }\n .concept h2{\n font-family:Georgia,serif;\n font-size:22px;\n line-height:1.25;\n margin:0;\n color:var(--navy);\n letter-spacing:-0.2px;\n }\n .concept p{\n margin:0;\n color:#324761;\n line-height:1.62;\n font-size:14.5px;\n }\n .concept-key{\n background:#FFF8E7;\n border-left:3px solid var(--gold);\n padding:10px 14px;\n border-radius:6px;\n font-size:14px !important;\n color:var(--navy) !important;\n }\n .concept-key strong{\n color:#7A5800;\n }\n .concept-flow{\n display:flex;\n align-items:center;\n gap:8px;\n flex-wrap:wrap;\n margin-top:4px;\n }\n .flow-step{\n display:inline-block;\n padding:7px 13px;\n border-radius:8px;\n font-size:12px;\n font-weight:700;\n letter-spacing:0.4px;\n border:1px solid var(--line);\n }\n .flow-step-dx{\n background:var(--blueSoft);\n color:var(--navy2);\n border-color:#C7DFF1;\n }\n .flow-step-tx{\n background:#FFF3E0;\n color:#BF360C;\n border-color:#FFCC80;\n }\n .flow-step-fu{\n background:#E8F5E9;\n color:#1B5E20;\n border-color:#A5D6A7;\n }\n .flow-arrow{\n color:var(--muted);\n font-weight:700;\n font-size:16px;\n }\n @media (max-width:960px){\n .concepts{ grid-template-columns:1fr; }\n }\n\n /* SECTIONS */\n .section{\n background:#fff;\n border:1px solid var(--line2);\n border-radius:22px;\n box-shadow:0 8px 22px rgba(13,27,42,.05);\n overflow:hidden;\n margin-top:16px;\n }\n\n .section-head{\n padding:20px 22px;\n border-bottom:1px solid var(--line);\n background:linear-gradient(135deg,#fff,#F8FBFE);\n display:flex;\n justify-content:space-between;\n gap:16px;\n align-items:flex-start;\n }\n\n .section-title{\n font-family:Georgia,serif;\n font-size:26px;\n margin:0 0 6px;\n color:var(--navy);\n line-height:1.15;\n }\n\n .section-sub{\n margin:0;\n color:var(--muted);\n font-size:14px;\n line-height:1.5;\n max-width:900px;\n }\n\n .badge{\n background:#EFF6FC;\n color:var(--blue);\n border:1px solid #BBD8EF;\n border-radius:999px;\n padding:7px 10px;\n font-weight:900;\n font-size:11px;\n text-transform:uppercase;\n white-space:nowrap;\n }\n\n .badge.orange{\n background:#FFF3E0;\n color:var(--orange);\n border-color:#FFD5A8;\n }\n\n .badge.green{\n background:#EAF8EF;\n color:var(--green);\n border-color:#BCE6CB;\n }\n\n .pad{\n padding:20px 22px;\n }\n\n .grid{\n display:grid;\n gap:14px;\n }\n\n .grid-2{\n grid-template-columns:1.15fr .85fr;\n }\n\n .grid-3{\n grid-template-columns:repeat(3,1fr);\n }\n\n .card{\n background:#fff;\n border:1px solid var(--line);\n border-radius:16px;\n padding:16px;\n box-shadow:0 3px 12px rgba(13,27,42,.04);\n }\n\n .soft-card{\n background:#FBFDFF;\n border:1px solid var(--line);\n border-radius:16px;\n padding:15px;\n }\n\n .mini-title{\n font-size:14px;\n text-transform:uppercase;\n letter-spacing:.08em;\n color:var(--blue);\n font-weight:950;\n margin:0 0 12px;\n }\n\n .mini-sub{\n margin:-8px 0 14px;\n font-size:13.5px;\n color:var(--muted);\n font-style:italic;\n font-weight:500;\n }\n\n .muted{\n color:var(--muted);\n font-size:13.5px;\n line-height:1.55;\n }\n\n /* METHOD */\n .method-grid{\n display:grid;\n grid-template-columns:repeat(4,1fr);\n gap:12px;\n }\n\n .method{\n border:1px solid var(--line);\n border-radius:14px;\n padding:14px;\n background:#FBFDFF;\n }\n\n .method strong{\n display:block;\n color:var(--navy);\n font-size:15px;\n margin-bottom:8px;\n }\n\n .weight{\n font-family:Georgia,serif;\n font-size:24px;\n color:var(--blue);\n font-weight:900;\n margin-bottom:5px;\n }\n\n /* MAP */\n .map-wrap{\n position:relative;\n min-height:680px;\n background:linear-gradient(180deg,#F8FBFE,#fff);\n border:1px solid var(--line);\n border-radius:18px;\n overflow:hidden;\n }\n\n .map-title{\n position:absolute;\n left:18px;\n top:16px;\n font-weight:950;\n color:var(--navy);\n font-size:17px;\n z-index:2;\n }\n\n .map-sub{\n position:absolute;\n left:18px;\n top:42px;\n color:var(--muted);\n font-size:13px;\n z-index:2;\n }\n\n .europe-map{\n position:absolute;\n inset:76px 18px 18px 18px;\n width:calc(100% - 36px);\n height:calc(100% - 94px);\n }\n\n .country-shape{\n stroke:#fff;\n stroke-width:1.6;\n stroke-linejoin:round;\n filter:drop-shadow(0 1px 2px rgba(13,27,42,.18));\n cursor:pointer;\n transition:.18s ease;\n }\n\n .country-shape:hover{\n filter:drop-shadow(0 3px 8px rgba(13,27,42,.28)) brightness(1.06);\n }\n\n .m-high{fill:#0D47A1}\n .m-adv{fill:#1E88E5}\n .m-mid{fill:#43A047}\n .m-em{fill:#F4A623}\n .m-na{fill:#CDD8E2}\n\n /* Country labels — font-size is set dynamically via JS attribute to counter-scale at zoom.\n We deliberately do NOT set font-size in CSS here, because CSS would override the SVG attribute.\n Only style other properties. */\n .country-label{\n font-weight:800;\n fill:#fff;\n text-anchor:middle;\n pointer-events:none;\n letter-spacing:0.5px;\n paint-order:stroke;\n stroke:rgba(13,27,42,.25);\n stroke-width:0.5;\n }\n /* .small and .tiny no longer set font-size — JS reads class to compute base size */\n\n .map-legend{\n position:absolute;\n right:14px;\n bottom:14px;\n background:#fff;\n border:1px solid var(--line);\n border-radius:11px;\n padding:9px 11px;\n font-size:11px;\n color:var(--muted);\n box-shadow:0 6px 14px rgba(13,27,42,.08);\n z-index:2;\n }\n\n .legend-row{\n display:flex;\n align-items:center;\n gap:7px;\n margin:3px 0;\n font-weight:700;\n }\n\n .dot{\n width:9px;\n height:9px;\n border-radius:50%;\n display:inline-block;\n background:#0D5FB8;\n }\n\n .dot.adv{background:#42A5F5}\n .dot.mid{background:#69C98A}\n .dot.em{background:#F6C85F}\n .dot.na{background:#CDD8E2}\n\n /* TABLE */\n .table{\n width:100%;\n border-collapse:collapse;\n font-size:14.5px;\n }\n\n .table th{\n text-align:left;\n color:#5B7489;\n font-size:13px;\n text-transform:uppercase;\n letter-spacing:.06em;\n border-bottom:1px solid var(--line);\n padding:9px;\n }\n\n .table td{\n border-bottom:1px solid #EDF2F6;\n padding:9px;\n vertical-align:middle;\n }\n\n .table tr:last-child td{\n border-bottom:none;\n }\n\n .level{\n display:inline-block;\n border-radius:999px;\n padding:4px 8px;\n font-size:13px;\n font-weight:900;\n }\n\n .level.high{\n background:#EAF3FA;\n color:#0D5FB8;\n }\n\n .level.adv{\n background:#EAF3FA;\n color:#1565C0;\n }\n\n .level.mid{\n background:#EAF8EF;\n color:#1B7F4A;\n }\n\n .level.em{\n background:#FFF3E0;\n color:#E65100;\n }\n\n .conf{\n display:inline-flex;\n gap:5px;\n align-items:center;\n }\n\n .conf:before{\n content:'';\n width:8px;\n height:8px;\n border-radius:50%;\n background:#C8D2DC;\n }\n\n .conf.high:before{background:var(--green)}\n .conf.medium:before{background:#F6C85F}\n .conf.low:before{background:#C8D2DC}\n\n /* TARGET BARS */\n .bar-row{\n display:grid;\n grid-template-columns:92px 1fr 120px;\n gap:10px;\n align-items:center;\n font-size:13px;\n margin:10px 0;\n }\n\n .bar-bg{\n height:12px;\n background:#EAF3FA;\n border-radius:999px;\n overflow:hidden;\n }\n\n .bar{\n height:100%;\n background:var(--blue);\n border-radius:999px;\n }\n\n .bar.green{background:#42B883}\n .bar.orange{background:#F6B73C}\n .bar.purple{background:#8A5CCF}\n .bar.gray{background:#B7C5D2}\n\n .warning-box{\n border:1px solid #FFD5A8;\n background:#FFF8EA;\n border-left:4px solid var(--orange);\n border-radius:12px;\n padding:13px 15px;\n color:#6B4A1D;\n font-size:13px;\n line-height:1.5;\n }\n\n /* USE CARDS */\n .use-grid{\n display:grid;\n grid-template-columns:1fr 1fr;\n gap:14px;\n }\n\n .use-card{\n border:1px solid var(--line);\n border-radius:18px;\n padding:18px;\n background:#fff;\n }\n\n .use-card h3{\n font-family:Georgia,serif;\n font-size:22px;\n margin:0 0 8px;\n color:var(--navy);\n }\n\n .use-card ul{\n margin:0;\n padding-left:20px;\n color:var(--muted);\n line-height:1.65;\n font-size:13.5px;\n }\n\n @media(max-width:1100px){\n .mock-shell{grid-template-columns:1fr}\n .mock-side{display:none}\n .kpis{grid-template-columns:repeat(2,1fr)}\n .grid-2,.grid-3,.method-grid,.use-grid{grid-template-columns:1fr}\n .page,.thera-header-inner{width:calc(100% - 28px)}\n }\n\n @media(max-width:640px){\n .mock-brand small{display:none}\n .kpis{grid-template-columns:1fr}\n .section-head{flex-direction:column}\n .map-wrap{min-height:420px}\n .bar-row{grid-template-columns:80px 1fr 80px}\n }\n /* COUNTRY DETAIL MODAL */\n .country-modal-backdrop{\n position:fixed;\n inset:0;\n background:rgba(13,27,42,0.6);\n backdrop-filter:blur(4px);\n -webkit-backdrop-filter:blur(4px);\n display:none;\n align-items:center;\n justify-content:center;\n z-index:1000;\n padding:20px;\n animation:fadeIn 0.2s ease-out;\n }\n .country-modal-backdrop.active{display:flex}\n\n @keyframes fadeIn{\n from{opacity:0}\n to{opacity:1}\n }\n @keyframes slideUp{\n from{transform:translateY(20px);opacity:0}\n to{transform:translateY(0);opacity:1}\n }\n\n .country-modal{\n background:var(--surface);\n border-radius:16px;\n max-width:780px;\n width:100%;\n max-height:85vh;\n overflow:hidden;\n box-shadow:0 24px 60px rgba(0,0,0,0.3);\n display:flex;\n flex-direction:column;\n animation:slideUp 0.3s ease-out;\n }\n\n .cm-header{\n background:linear-gradient(135deg, var(--navy), var(--navy2));\n color:#fff;\n padding:22px 28px;\n display:flex;\n align-items:center;\n justify-content:space-between;\n gap:16px;\n }\n .cm-header-left{display:flex;align-items:center;gap:14px;flex:1}\n .cm-flag{font-size:32px;line-height:1}\n .cm-title{font-size:22px;font-weight:700;margin:0;line-height:1.2}\n .cm-subtitle{font-size:13px;opacity:.85;margin:2px 0 0;font-weight:400}\n .cm-close{\n background:rgba(255,255,255,.15);\n border:none;\n color:#fff;\n width:36px;\n height:36px;\n border-radius:50%;\n cursor:pointer;\n font-size:18px;\n display:flex;\n align-items:center;\n justify-content:center;\n transition:background .15s;\n }\n .cm-close:hover{background:rgba(255,255,255,.28)}\n\n .cm-stats{\n display:flex;\n gap:0;\n background:#F8FAFC;\n border-bottom:1px solid var(--line);\n }\n .cm-stat{\n flex:1;\n padding:16px 20px;\n text-align:center;\n border-right:1px solid var(--line);\n }\n .cm-stat:last-child{border-right:none}\n .cm-stat-num{\n font-size:24px;\n font-weight:700;\n color:var(--blue);\n line-height:1;\n }\n .cm-stat-label{\n font-size:11px;\n text-transform:uppercase;\n letter-spacing:.5px;\n color:var(--muted);\n margin-top:6px;\n }\n\n .cm-body{\n overflow-y:auto;\n padding:24px 28px;\n flex:1 1 auto;\n min-height:0;\n -webkit-overflow-scrolling:touch;\n }\n\n .cm-section{margin-bottom:24px}\n .cm-section:last-child{margin-bottom:0}\n .cm-section-title{\n font-size:13px;\n font-weight:700;\n color:var(--navy);\n margin:0 0 12px;\n text-transform:uppercase;\n letter-spacing:.5px;\n display:flex;\n align-items:center;\n gap:8px;\n }\n .cm-section-title::before{\n content:'';\n display:inline-block;\n width:4px;\n height:16px;\n background:var(--blue);\n border-radius:2px;\n }\n\n .cm-centers-list{\n display:grid;\n grid-template-columns:1fr;\n gap:8px;\n }\n .cm-center{\n background:#FAFBFC;\n border:1px solid var(--line);\n border-radius:8px;\n padding:10px 14px;\n font-size:13px;\n line-height:1.4;\n display:flex;\n align-items:flex-start;\n gap:10px;\n transition:border-color .15s;\n }\n .cm-center:hover{border-color:var(--blue2)}\n .cm-center-num{\n background:var(--blue);\n color:#fff;\n font-size:11px;\n font-weight:700;\n width:22px;\n height:22px;\n border-radius:50%;\n display:flex;\n align-items:center;\n justify-content:center;\n flex-shrink:0;\n }\n .cm-center-info{flex:1;min-width:0}\n .cm-center-name{font-weight:600;color:var(--text)}\n .cm-center-city{font-size:12px;color:var(--muted);margin-top:2px}\n\n /* Show more / centers info wrapper */\n .cm-centers-info{\n font-size:12px;\n color:var(--muted);\n padding:6px 12px;\n background:var(--blueSoft);\n border-radius:6px;\n margin-bottom:4px;\n }\n .cm-centers-info strong{color:var(--blue)}\n .cm-centers-toggle{\n background:#fff;\n border:1px dashed var(--blue);\n color:var(--blue);\n border-radius:8px;\n padding:11px 14px;\n cursor:pointer;\n font-size:13px;\n font-weight:600;\n display:flex;\n align-items:center;\n justify-content:space-between;\n transition:background .15s, transform .15s;\n margin-top:6px;\n width:100%;\n }\n .cm-centers-toggle:hover{\n background:var(--blueSoft);\n transform:translateY(-1px);\n }\n .cm-toggle-arrow{\n font-size:11px;\n transition:transform .2s;\n }\n\n /* Point 4a: clickable \"+ X autres centres\" row → mailto contact */\n .cm-center-more{\n background:linear-gradient(135deg, #FFF8EA, #FFFBF0);\n border:1px dashed var(--gold);\n 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border-radius:16px 16px 0 0;\n animation:slideUpMobile 0.3s ease-out;\n }\n @keyframes slideUpMobile{\n from{transform:translateY(100%)}\n to{transform:translateY(0)}\n }\n .cm-header{padding:18px 20px}\n .cm-title{font-size:18px}\n .cm-body{padding:18px 20px}\n .cm-stat-num{font-size:20px}\n }\n\n /* MAP ZOOM SYSTEM */\n .map-zoom-container{\n position:absolute;\n inset:50px 18px 50px 18px;\n background:linear-gradient(180deg, #EAF3FA, #DCE9F3);\n border-radius:12px;\n overflow:hidden;\n }\n .map-zoom-controls{\n position:absolute;\n top:12px;\n right:12px;\n display:flex;\n flex-direction:column;\n gap:4px;\n z-index:10;\n background:#fff;\n border-radius:8px;\n box-shadow:0 2px 8px rgba(13,27,42,0.15);\n padding:4px;\n }\n .map-zoom-btn{\n width:32px;\n height:32px;\n border:none;\n background:#fff;\n color:var(--navy);\n font-size:18px;\n font-weight:600;\n cursor:pointer;\n border-radius:6px;\n display:flex;\n align-items:center;\n justify-content:center;\n transition:background .15s, color .15s;\n line-height:1;\n padding:0;\n }\n .map-zoom-btn:hover{\n background:var(--blueSoft);\n color:var(--blue);\n }\n .map-zoom-btn:active{transform:scale(0.95)}\n .map-zoom-btn:disabled{\n opacity:.4;\n cursor:not-allowed;\n background:#fff;\n color:var(--muted);\n }\n .map-zoom-reset{font-size:14px}\n .map-zoom-level{\n position:absolute;\n bottom:12px;\n right:12px;\n z-index:10;\n background:rgba(13,27,42,0.8);\n color:#fff;\n padding:4px 10px;\n border-radius:12px;\n font-size:11px;\n font-weight:600;\n font-variant-numeric:tabular-nums;\n pointer-events:none;\n opacity:0;\n transition:opacity .2s;\n }\n .map-zoom-level.visible{opacity:1}\n\n /* Override the absolute positioning of europe-map since it's now inside .map-zoom-container */\n .map-zoom-container .europe-map{\n position:relative;\n inset:auto;\n width:100%;\n height:100%;\n display:block;\n transition:none;\n cursor:grab;\n }\n .map-zoom-container .europe-map.zoomed{cursor:grab}\n .map-zoom-container .europe-map:active{cursor:grabbing}\n\n /* Labels show as country code by default, switch to centers count at high zoom.\n font-size is set dynamically by JS to counter-scale at zoom. */\n .country-label.show-centers{\n font-weight:700;\n }\n\n /* Country shape — hover only, no click */\n .country-shape{cursor:default;transition:opacity .15s, filter .15s}\n .country-shape:hover{\n opacity:.85;\n filter:brightness(1.1);\n }\n\n /* Clickable table rows */\n .country-row:hover{\n background:var(--blueSoft) !important;\n }\n\n","html":"
\n
\n
\n

Global overview

\n

European overview of data, centers, trials and expertise in theranostics.

\n
\n
\n
\n\n
\n
\n
🌍
\n
\n
Tracked countries
\n
9
\n
FR, BE, CH, LU, NL, DE, ES, IT, PT
\n
\n
\n\n
\n
🏥
\n
\n
Estimated RIV centers
\n
200–230
\n
estimate early 2026
\n
\n
\n\n
\n
🧪
\n
\n
Active theranostic trials
\n
16
\n
CTIS · ClinicalTrials.gov · ICTRP
\n
\n
\n\n
\n
🎯
\n
\n
Tracked targets
\n
10
\n
PSMA, SSTR, FAP, GRPR, CXCR4, NIS, NET-norepi, CCK2, integrin αvβ6, HER2
\n
\n
\n
\n\n
\n
\n
\n \n Concept fondateur\n
\n

What is theranostics?

\n

\n Theranostics refers to a medical approach combining diagnosis and treatment around the same biological target. In nuclear medicine, it takes a particularly accomplished form: a radiotracer identifies the target through imaging, then a therapeutic radioligand uses the same target to deliver personalized treatment.\n

\n
\n Diagnostic\n →\n Therapy\n →\n Follow-up\n
\n
\n\n
\n
\n \n Therapeutic application\n
\n

What is targeted radionuclide therapy (RIV)?

\n

\n Targeted radionuclide therapy (RIV) is a nuclear medicine treatment approach that uses a targeted radiopharmaceutical to deliver radiation directly inside diseased cells or tissues. The treatment combines a carrier molecule, capable of recognizing a specific biological target, with a therapeutic radioactive isotope, enabling selective irradiation of the disease from inside the body.\n

\n

\n RIV is the major therapeutic application of theranostics in nuclear medicine.\n

\n
\n
\n\n
\n
\n
\n

Theranostic maturity by country

\n

\n Qualitative index based on the number of centers and clinical trials in theranostics and RIV per country.\n

\n
\n estimated index\n
\n\n
\n
\n
Estimated maturity map
\n
Hover over a country for details. Click a table row on the right to view centers and trials.
\n\n
\n
\n \n \n \n
\n
100%
\n\n \n\n \n \n \n \n \n \n \n \n \n\n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n \n \n Spain — advanced\n \n \n France — very advanced\n \n \n Germany — very advanced\n \n \n Italy — advanced\n \n \n Portugal — emerging\n \n \n Switzerland — intermediate / advanced\n \n \n Belgium — intermediate / advanced\n \n \n Netherlands — advanced\n \n \n Luxembourg — limited market\n \n\n \n ES\n FR\n DE\n IT\n PT\n CH\n BE\n NL\n LU\n\n \n\n
\n
Very advanced
\n
Advanced
\n
Intermediate
\n
Emerging
\n
Out of scope / data not integrated
\n
\n
\n\n
\n\n
\n

Status by country

\n

Estimate late 2025 – early 2026

\n\n \n \n \n \n \n \n \n \n \n \n
PaysCentres RIVEssaisMaturity
\n\n

\n Sources: CTIS registry, ICTRP, ClinicalTrials.gov · Reference document \"RIV/RLT clinical trials — European mapping 2026\" available on request.\n
\n Notation \"8 (+1)\" = 8 confirmed trials + 1 to validate via secondary sources.\n

\n
\n
\n
\n\n
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★ Molecule of the Month · May 2026
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¹⁷⁷Lu-PSMA-617

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[¹⁷⁷Lu]Lu-PSMA-617 · INN: lutetium (¹⁷⁷Lu) vipivotide tetraxetan · Brand: Pluvicto®

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The first therapeutic radioligand used in routine European oncology practice. Approved by the EMA in 2022 for PSMA-positive metastatic castration-resistant prostate cancer (mCRPC), it redefined the post-taxane standard of care and continues to expand toward pre-taxane (PSMAfore) and oligometastatic indications.

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2022
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EMA approval
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8
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Active EU trials
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200+
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EU treatment centers
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38 %
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↓ mortality risk (VISION)
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— Mechanism of action
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How ¹⁷⁷Lu-PSMA-617 works

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PSMA-617 is a small peptide ligand that binds with high affinity to the Prostate-Specific Membrane Antigen, a transmembrane protein overexpressed in 90% of metastatic prostate cancer cells. The ligand chelated with lutetium-177 (pure β⁻ emitter, half-life 6.7 days, tissue range 1.7 mm) delivers localized irradiation to PSMA-expressing tumor cells while relatively sparing healthy tissues.

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🎯
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PSMA binding
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PSMA-617 recognizes the target expressed on the surface of tumor cells
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→
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⚛️
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Internalization
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The ligand-PSMA complex is endocytosed into the cell
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→
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☢️
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β⁻ emission
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¹⁷⁷Lu emits short-range electrons (1.7 mm)
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→
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💥
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DNA damage
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Lethal double-strand breaks in tumor cells
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— Indications
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Approved and in development

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\n ✓ EMA approved\n

Post-taxane mCRPC

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Metastatic castration-resistant prostate cancer after taxane chemotherapy, PSMA-positive on [⁶⁸Ga]Ga-PSMA-11 or [¹⁸F]F-PSMA imaging. Basis of the VISION trial (2021).

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\n ⏳ Phase 3\n

Pre-taxane mCRPC (PSMAfore)

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Extension to the pre-taxane line compared with switch hormonal therapy. CTIS 2023-507772-50-00 · 6 EU countries recruiting.

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\n ⏳ Phase 2\n

Oligometastatic prostate cancer

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Hormone-sensitive disease with low metastatic burden, ongoing trial in the Netherlands (NCT04443062). Early intensified treatment strategy.

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\n ⏳ Trials\n

Combinations (β + α, +PARP)

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The DUET trial (Netherlands) combines ¹⁷⁷Lu-PSMA + ²²³Ra-dichloride. Other trials are exploring combinations with PARP inhibitors.

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— Active EU clinical trials
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Active PSMA clinical trials in Europe

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PSMAfore
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CTIS 2023-507772-50-00 · NCT04689828
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\n 🇫🇷 🇪🇸 🇮🇹 🇩🇪 🇧🇪 🇳🇱\n
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RADIODOSE
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CTIS 2024-512338-13-00 · NCT06531499
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\n 🇩🇪 🇳🇱 🇪🇸 🇨🇭\n
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DUET (β+α combination)
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CTIS 2024-518985-29-02
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\n 🇳🇱\n
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¹⁷⁷Lu-PSMA oligometastatic
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CTIS 2023-509881-39-00 · NCT04443062
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\n 🇳🇱\n
\n
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\n
LUBASKET (basket trial)
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CTIS 2024-519346-75-00 · NCT05867615
\n
\n 🇮🇹\n
\n
\n

\n View all PSMA trials →\n

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\n\n \n
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— Experienced centers
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Early European prescribers

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Non-exhaustive selection of centers that have treated more than 100 patients with ¹⁷⁷Lu-PSMA-617 since 2022.

\n
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\n 🇩🇪\n
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Universitätsklinikum Heidelberg
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Heidelberg
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\n 🇩🇪\n
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LMU Klinikum München
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München
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\n
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\n 🇮🇹\n
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Humanitas Research Hospital
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Rozzano (Milano)
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\n
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\n 🇪🇸\n
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Vall d'Hebron Hospital
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Barcelona
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\n
\n
\n 🇳🇱\n
\n
Erasmus MC
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Rotterdam
\n
\n
\n
\n 🇫🇷\n
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Institut Curie
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Paris
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\n
\n
\n 🇨🇭\n
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Inselspital Bern
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Bern
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\n
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\n 🇧🇪\n
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UZ Leuven
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Leuven
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\n\n \n
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— Reference publications
\n

Key reading for nuclear medicine physicians

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\n
Sartor O, et al. Lutetium-177–PSMA-617 for Metastatic Castration-Resistant Prostate Cancer (VISION trial)
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N Engl J Med · 2021 · 385:1091-1103 · IF 158
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\n
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Hofman MS, et al. [177Lu]Lu-PSMA-617 versus cabazitaxel in patients with metastatic castration-resistant prostate cancer (TheraP)
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Lancet · 2021 · 397:797-804 · IF 168
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\n
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Chi KN, et al. Safety analyses of the phase 3 VISION trial of [¹⁷⁷Lu]Lu-PSMA-617 in mCRPC
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Eur Urol · 2024 · 85(4):382-391 · IF 24
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\n
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Morris MJ, et al. ¹⁷⁷Lu-PSMA-617 vs ARPI change in taxane-naive mCRPC (PSMAfore)
\n
Lancet · 2024 · 404(10459):1227-1239 · IF 168
\n
\n\n
\n Nucleascope editorial note: This selection of publications is curated by our medical editorial team. The data presented are drawn from peer-reviewed publications and recognized conferences.\n
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\n\n \n
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\n
\n
"},"recommendations":{"css":"\n :host, .source-body { margin: 0; padding: 0; background: #F5F3EF; }\n /* Verrou de scroll quand la modale est ouverte (classe globale) */\n .source-body.modal-open { overflow: hidden; }\n /* Le fragment apporte ses propres styles scopés sous #pane-recommandations */\n\n\n /* Variables CSS scopées localement pour éviter tout effet global sur le monolithique */\n #pane-recommandations{\n --bg:#F5F3EF; --surface:#fff; --text:#13213A; --muted:#5B7489;\n --line:#D5E5F0; --line2:#E0DDD7; --navy:#0D1B2A; --navy2:#0D3B5C;\n --blue:#1565C0; --blue2:#42A5F5; --blueSoft:#EAF3FA; --gold:#C89B3C;\n --green:#1B7F4A; --orange:#E65100; --purple:#6A1B9A; --red:#C62828;\n --shadow:0 10px 26px rgba(13,27,42,.08); --max:1500px;\n font-family:'DM Sans',Inter,system-ui,-apple-system,BlinkMacSystemFont,\"Segoe UI\",sans-serif;color:var(--text);background:var(--bg);padding:28px 18px 44px;\n }\n #pane-recommandations *{box-sizing:border-box;}\n #pane-recommandations 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.thera-header{flex-direction:column;}#pane-recommandations .header-actions{justify-content:flex-start;}#pane-recommandations .thera-header h1{font-size:28px;}#pane-recommandations .tiles-grid{grid-template-columns:1fr;}#pane-recommandations .reco-tile ul{columns:1;}#pane-recommandations .selection-lines{grid-template-columns:1fr;}#pane-recommandations .sources-grid{grid-template-columns:1fr;}}\n ","html":"
\n \n\n
\n

Recommendations & procedures

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⚠️
Educational aid — not a binding protocolThis tool summarises the recommendations of learned societies (EANM/SNMMI, IAEA, DGN, national societies). Any therapeutic decision must be validated in a multidisciplinary team (MDT) meeting and comply with the local centre protocol, the current marketing authorisation and the individual medical assessment. Doses, frequencies and dose adjustments are indicative.
\n
\n
Selected treatment:¹⁷⁷Lu-PSMA-617
Selected profile:Nuclear medicine physician
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Sources & recommendations from learned societies

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📚 Reference standards & guidelines
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🎯

Titre

Sources

\n\n \n
"},"research":{"targetLabels":{"PSMA":{"name":"Prostate-Specific Membrane Antigen","full":"PSMA"},"SSTR":{"name":"Somatostatin Receptor (Type 2)","full":"SSTR"},"FAP":{"name":"Fibroblast Activation Protein","full":"FAP"},"GRPR":{"name":"Gastrin-Releasing Peptide Receptor","full":"GRPR"},"CXCR4":{"name":"Chemokine Receptor Type 4","full":"CXCR4"},"HER2":{"name":"Human Epidermal growth factor Receptor 2","full":"HER2"},"MULTI":{"name":"Basket study — PSMA / SSTR2 / GRPR","full":"BASKET"}},"countryFlags":{"France":"🇫🇷","Allemagne":"🇩🇪","Italie":"🇮🇹","Espagne":"🇪🇸","Pays-Bas":"🇳🇱","Belgique":"🇧🇪","Suisse":"🇨🇭","Portugal":"🇵🇹","Luxembourg":"🇱🇺","Royaume-Uni":"🇬🇧","Autriche":"🇦🇹"},"css":"\n /* Masquer topbar/sidebar/footer quand la page est chargée en iframe (intégration index.html) */\n :host.is-iframe .topbar,\n :host.is-iframe .mock-topbar,\n :host.is-iframe .mock-side,\n :host.is-iframe .footer {\n display: none !important;\n }\n :host.is-iframe .mock-shell {\n grid-template-columns: 1fr !important;\n }\n :host.is-iframe .source-body {\n padding-top: 0 !important;\n }\n\n\n :host{\n --bg:#F5F3EF;\n --surface:#fff;\n --text:#13213A;\n --muted:#5B7489;\n --line:#D5E5F0;\n --line2:#E0DDD7;\n --navy:#0D1B2A;\n --navy2:#0D3B5C;\n --blue:#1565C0;\n --blue2:#42A5F5;\n --blueSoft:#EAF3FA;\n --gold:#C89B3C;\n --green:#1B7F4A;\n --orange:#E65100;\n --purple:#6A1B9A;\n --red:#C62828;\n --shadow:0 10px 26px rgba(13,27,42,.08);\n --max:1400px;\n }\n *{box-sizing:border-box}\n .source-body{\n margin:0;\n background:var(--bg);\n color:var(--text);\n font-family:'DM Sans', Inter, system-ui, -apple-system, BlinkMacSystemFont, \"Segoe UI\", sans-serif;\n }\n a{text-decoration:none;color:inherit}\n\n /* HEADER */\n .topbar{\n background:#fff;\n border-bottom:1px solid var(--line2);\n padding:14px 24px;\n display:flex;\n align-items:center;\n justify-content:space-between;\n position:sticky;\n top:0;\n z-index:50;\n }\n 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color:#fff;\n line-height:1;\n }\n .hs-label{\n font-size:10px;\n text-transform:uppercase;\n letter-spacing:1px;\n opacity:.78;\n font-weight:600;\n }\n\n .hero-update-info{\n background:rgba(255,255,255,0.08);\n border:1px solid rgba(255,255,255,0.18);\n border-radius:10px;\n padding:10px 16px;\n display:flex;\n align-items:center;\n gap:12px;\n backdrop-filter:blur(6px);\n }\n .hui-icon{font-size:20px;line-height:1}\n .hui-label{\n font-size:9px;\n text-transform:uppercase;\n letter-spacing:1px;\n opacity:.7;\n font-weight:600;\n color:#fff;\n }\n .hui-date{\n font-size:13px;\n font-weight:600;\n color:#fff;\n margin-top:2px;\n }\n\n /* VISUALIZATIONS */\n .viz-grid{\n display:grid;\n grid-template-columns:1fr 1fr;\n gap:18px;\n margin-bottom:24px;\n }\n @media (max-width:900px){\n .viz-grid{grid-template-columns:1fr}\n }\n .viz-card{\n background:#fff;\n border:1px solid var(--line);\n border-radius:12px;\n padding:20px 22px;\n box-shadow:var(--shadow);\n }\n .viz-header{margin-bottom:18px}\n .viz-title{\n font-size:15px;\n font-weight:700;\n color:var(--navy);\n margin:0 0 4px;\n }\n .viz-sub{\n font-size:12px;\n color:var(--muted);\n margin:0;\n line-height:1.4;\n }\n .viz-body{display:flex;flex-direction:column;gap:9px}\n\n .viz-row{\n display:grid;\n grid-template-columns:90px 1fr 30px;\n align-items:center;\n gap:10px;\n }\n .viz-label{\n font-size:12px;\n font-weight:600;\n color:var(--text);\n }\n .viz-bar-bg{\n background:#F1F4F8;\n border-radius:4px;\n height:22px;\n position:relative;\n overflow:hidden;\n }\n .viz-bar{\n height:100%;\n border-radius:4px;\n transition:width .4s ease-out;\n position:relative;\n }\n .viz-count{\n font-size:13px;\n font-weight:700;\n color:var(--navy);\n text-align:right;\n font-variant-numeric:tabular-nums;\n }\n\n /* Target colors (one per cible) */\n .viz-bar.target-psma{background:linear-gradient(90deg, #1565C0, #42A5F5)}\n .viz-bar.target-sstr{background:linear-gradient(90deg, #1B7F4A, #4CAF50)}\n .viz-bar.target-fap{background:linear-gradient(90deg, #E65100, #FF9800)}\n .viz-bar.target-grpr{background:linear-gradient(90deg, #6A1B9A, #9C27B0)}\n .viz-bar.target-cxcr4{background:linear-gradient(90deg, #C62828, #EF5350)}\n .viz-bar.target-multi{background:linear-gradient(90deg, #00695C, #26A69A)}\n\n /* Country bars - uniform blue */\n .viz-bar.country{background:linear-gradient(90deg, #0D3B5C, #1565C0)}\n\n .viz-flag{\n display:inline-block;\n margin-right:4px;\n font-size:14px;\n vertical-align:-1px;\n }\n\n /* MAIN CONTAINER */\n .container{\n max-width:var(--max);\n margin:0 auto;\n padding:32px 24px 60px;\n }\n\n /* FILTERS BAR — Compact horizontal layout (v6) */\n .filters-bar{\n background:#fff !important;\n border:1px solid var(--line);\n border-radius:12px;\n padding:16px 18px;\n margin-bottom:24px;\n box-shadow:var(--shadow);\n display:grid !important;\n grid-template-columns:1fr 1fr 0.8fr 1.5fr auto !important;\n gap:10px !important;\n align-items:end;\n }\n /* v5: keep filters strictly in line. Only collapse on very small mobile (<480px). */\n @media (max-width:480px){\n .filters-bar{\n grid-template-columns:1fr !important;\n }\n }\n .filter-group{\n display:flex;\n flex-direction:column;\n gap:6px;\n min-width:0;\n }\n .filter-label{\n font-size:10px;\n font-weight:700;\n text-transform:uppercase;\n letter-spacing:.5px;\n color:var(--muted);\n }\n .filter-select{\n padding:8px 10px;\n border:1px solid var(--line);\n border-radius:8px;\n background:#fff;\n font-size:13px;\n color:var(--text);\n cursor:pointer;\n transition:border-color .15s;\n width:100%;\n }\n .filter-select:hover{border-color:var(--blue2)}\n .filter-select:focus{outline:none;border-color:var(--blue);box-shadow:0 0 0 3px rgba(21,101,192,.15)}\n .filter-search{\n padding:9px 12px;\n border:1px solid var(--line);\n border-radius:8px;\n background:#fff;\n font-size:14px;\n width:100%;\n }\n .filter-reset{\n background:var(--blueSoft);\n color:var(--blue);\n border:none;\n padding:9px 16px;\n border-radius:8px;\n font-weight:600;\n font-size:13px;\n cursor:pointer;\n transition:background .15s;\n }\n .filter-reset:hover{background:#D6E8F5}\n\n .results-count{\n margin-bottom:18px;\n font-size:14px;\n color:var(--muted);\n }\n .results-count strong{color:var(--navy);font-weight:700}\n\n /* GROUPS */\n .target-group{\n margin-bottom:28px;\n background:#fff;\n border:1px solid var(--line);\n border-radius:12px;\n overflow:hidden;\n box-shadow:var(--shadow);\n }\n .tg-header{\n padding:16px 22px;\n color:#fff;\n display:flex;\n align-items:center;\n justify-content:space-between;\n gap:12px;\n }\n .tg-header.psma{background:linear-gradient(90deg, #1565C0, #42A5F5)}\n .tg-header.sstr{background:linear-gradient(90deg, #1B7F4A, #4CAF50)}\n .tg-header.fap{background:linear-gradient(90deg, #E65100, #FF9800)}\n .tg-header.grpr{background:linear-gradient(90deg, #6A1B9A, #9C27B0)}\n .tg-header.cxcr4{background:linear-gradient(90deg, #C62828, #EF5350)}\n .tg-header.multi{background:linear-gradient(90deg, #00695C, #26A69A)}\n\n .tg-target{\n font-size:13px;\n font-weight:700;\n text-transform:uppercase;\n letter-spacing:.5px;\n background:rgba(255,255,255,.18);\n padding:5px 10px;\n border-radius:6px;\n }\n .tg-name{\n flex:1;\n font-size:18px;\n font-weight:700;\n margin:0 0 0 12px;\n }\n .tg-count{\n font-size:13px;\n opacity:.9;\n font-weight:600;\n }\n .tg-body{padding:18px 22px}\n\n /* TRIAL CARD */\n .trial-card{\n background:#fff;\n border:1px solid var(--line);\n border-radius:10px;\n padding:18px 20px;\n margin-bottom:12px;\n transition:border-color .15s, transform .15s;\n }\n .trial-card:hover{\n border-color:var(--blue2);\n transform:translateY(-1px);\n }\n .trial-card:last-child{margin-bottom:0}\n\n .tc-header{\n display:flex;\n align-items:flex-start;\n justify-content:space-between;\n gap:12px;\n margin-bottom:8px;\n }\n .tc-name{\n font-size:17px;\n font-weight:700;\n color:var(--navy);\n margin:0;\n line-height:1.3;\n }\n .tc-ids{\n font-size:11px;\n color:var(--muted);\n font-family:'SF Mono', Menlo, monospace;\n text-align:right;\n flex-shrink:0;\n }\n .tc-agent{\n font-size:14px;\n color:var(--text);\n margin:4px 0 12px;\n }\n .tc-agent strong{color:var(--navy);font-weight:600}\n\n .tc-meta{\n display:flex;\n flex-wrap:wrap;\n gap:8px;\n align-items:center;\n }\n .tc-pill{\n background:#F3F8FB;\n color:var(--navy);\n padding:4px 10px;\n border-radius:14px;\n font-size:12px;\n font-weight:600;\n display:inline-flex;\n align-items:center;\n gap:4px;\n }\n .tc-pill.ctgov{\n background:#E8F5E9;\n color:var(--green);\n }\n .tc-flag{font-size:14px}\n\n .tc-comment{\n font-size:12px;\n color:var(--muted);\n font-style:italic;\n margin-top:10px;\n padding-top:10px;\n border-top:1px solid var(--line);\n line-height:1.4;\n }\n\n /* C2: Link to ClinicalTrials.gov */\n .tc-link{\n display:flex;\n align-items:center;\n justify-content:space-between;\n margin-top:12px;\n padding:10px 14px;\n background:linear-gradient(90deg, #F3F8FB, #EAF3FA);\n border-radius:8px;\n color:var(--blue);\n font-size:13px;\n font-weight:600;\n text-decoration:none;\n transition:background .15s, transform .15s;\n border:1px solid transparent;\n }\n .tc-link:hover{\n background:linear-gradient(90deg, #EAF3FA, #DCE9F3);\n border-color:var(--blue2);\n transform:translateX(2px);\n }\n .tc-link-arrow{\n font-size:16px;\n transition:transform .15s;\n }\n .tc-link:hover .tc-link-arrow{transform:translateX(3px)}\n\n .empty-state{\n text-align:center;\n padding:60px 20px;\n color:var(--muted);\n }\n .empty-state h3{color:var(--text);margin:0 0 8px}\n\n /* FOOTER */\n .footer{\n background:var(--navy);\n color:#fff;\n padding:32px 24px;\n margin-top:60px;\n }\n .footer-inner{\n max-width:var(--max);\n margin:0 auto;\n display:flex;\n justify-content:space-between;\n align-items:center;\n flex-wrap:wrap;\n gap:20px;\n }\n .footer-brand{font-weight:700;font-size:16px}\n .footer-sources{font-size:12px;opacity:.7;max-width:500px;line-height:1.5}\n\n /* RESPONSIVE */\n @media (max-width:768px){\n .hero{padding:32px 20px 48px}\n .hero h1{font-size:26px}\n .hero p{font-size:14px}\n .hero-stats{gap:20px}\n .hs-num{font-size:28px}\n .filters-bar{padding:14px 16px;gap:12px}\n .filter-group{min-width:130px}\n .container{padding:20px 16px 40px}\n .tg-name{font-size:16px}\n .tc-header{flex-direction:column;gap:4px}\n .tc-ids{text-align:left}\n }\n","html":"
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— European mapping 2026
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Active RIV / RLT clinical trials in Europe

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29 targeted radionuclide therapy (RIV) and radioligand therapy (RLT) trials currently active in Europe, broken down by biological target and participating countries. Sources: CTIS, ClinicalTrials.gov, ICTRP.

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29
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Identified trials
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10
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Countries analyzed
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7
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Cibles biologiques
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13
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PSMA-dominant trials
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📅
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Data updated
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mai 2026
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Trials by biological target

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Breakdown of the 29 active trials by target molecule · one color per target

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Trials by participating country

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Research activity by country · one trial can be active in several countries

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\n 29 trials · 7 biological targets\n
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"},"directory":{"css":"\n\n\n\n#thera-module .thera-subtabs {display: flex; gap: 8px; margin: 0 0 14px; padding: 8px 0 0 0; padding-bottom: 2px; border-bottom: 2px solid #E0DDD7; position: sticky; top: 60px; background: #fffaf0; z-index: 30;}\n#thera-module .thera-subtab {background: transparent; border: none; padding: 10px 20px; font-family: Georgia,\"Times New Roman\",serif; font-size: 15px; font-weight: 600; color: #647086; cursor: pointer; transition: all .2s; border-radius: 8px 8px 0 0; margin-bottom: -2px; border-bottom: 2px solid transparent; display: inline-flex; align-items: center; gap: 7px;}\n#thera-module .thera-subtab:hover {background: rgba(13,27,42,.06); color: #0D1B2A;}\n#thera-module .thera-subtab.active {color: #0D1B2A; background: #fffaf0; border-bottom-color: #1565C0; font-weight: 700;}\n#thera-module .thera-subtab[data-thera-subtab=\"partner\"]{background: #FFE8C7; color: #0D1B2A !important; border: 1px solid #FFB060; border-radius: 8px; margin: 0 4px; padding: 9px 16px; font-weight: 700; box-shadow: 0 1px 3px rgba(230,81,0,.12);}\n#thera-module .thera-subtab[data-thera-subtab=\"partner\"]:hover{background: #FFD9A3; border-color: #FF9800; box-shadow: 0 2px 6px rgba(230,81,0,.2); color: #0D1B2A;}\n#thera-module .thera-subtab[data-thera-subtab=\"partner\"].active{background: #FFD9A3; border-color: #FF9800; border-bottom-color: #FF9800; box-shadow: 0 2px 6px rgba(230,81,0,.2);}\n#thera-module .theramap-root {--navy: #071a33; --navy2: #0d2a50; --ink: #12223d; --muted: #647086; --paper: #fffaf0; --card: #ffffff; --soft: #f8efe0; --line: #e5d6bf; --gold: #b18035; --green: #1f7a3a; --green-soft: #ecf8ef; --purple: #7a3fb2; --purple-soft: #f5ecfb; --orange: #c56e00; --orange-soft: #fff1dc; --blue: #2e6fb5; --blue-soft: #edf6ff; --red: #b84a42; --shadow: 0 18px 45px rgba(8,19,36,.10); --font-serif: Georgia,\"Times New Roman\",serif; --font-sans: Inter,ui-sans-serif,system-ui,-apple-system,BlinkMacSystemFont,\"Segoe UI\",sans-serif; color: var(--ink); font-family: var(--font-sans); background: radial-gradient(circle at 85% 5%, rgba(255,255,255,.96), transparent 32%),\n radial-gradient(circle at 10% 50%, rgba(239,220,185,.78), transparent 46%),\n linear-gradient(135deg,#fffaf0,#f2e3c6); border-radius: 18px; padding: 6px 0 12px; margin-top: 8px;}\n#thera-module .theramap-root .page {max-width: 100%; width: 100%; margin: 0; padding: 36px 36px 46px; background: transparent; border-radius: 18px; color: var(--ink);}\n#thera-module .theramap-root .hero {display: grid; grid-template-columns: 1.1fr .9fr; gap: 28px; align-items: end; margin-bottom: 22px;}\n#thera-module .theramap-root .eyebrow {color: #a96c13; text-transform: uppercase; letter-spacing: .08em; font-size: 13px; font-weight: 900; margin-bottom: 8px;}\n#thera-module .theramap-root h1 {margin: 0 0 12px; font-family: var(--font-serif); font-size: clamp(34px,4vw,54px); line-height: .98; color: #081b35; letter-spacing: -.02em;}\n#thera-module .theramap-root .subtitle {max-width: 820px; margin: 0; color: #46536a; font-size: 15px; line-height: 1.6;}\n#thera-module .theramap-root .legend {background: rgba(255,255,255,.80); border: 1px solid var(--line); border-radius: 20px; padding: 16px 18px; box-shadow: 0 10px 25px rgba(36,23,5,.06);}\n#thera-module .theramap-root .legend-title {font-size: 12px; font-weight: 950; letter-spacing: .08em; text-transform: uppercase; color: #34425b; margin-bottom: 12px;}\n#thera-module .theramap-root .legend-grid {display: grid; grid-template-columns: repeat(2,minmax(0,1fr)); gap: 10px 14px; font-size: 13px; font-weight: 850;}\n#thera-module .theramap-root .dot {width: 12px; height: 12px; border-radius: 50%; display: inline-block; margin-right: 8px; vertical-align: -1px;}\n#thera-module .theramap-root .dot.standard {background: var(--green);}\n#thera-module .theramap-root .dot.research {background: var(--purple);}\n#thera-module .theramap-root .dot.academic {background: var(--orange);}\n#thera-module .theramap-root .dot.historic {background: var(--blue);}\n#thera-module .theramap-root .legend-help {margin-top: 12px; padding-top: 12px; border-top: 1px dashed #d8c6a8; color: #5c6678; font-size: 12.5px; line-height: 1.45;}\n#thera-module .theramap-root .summary {display: grid; grid-template-columns: repeat(4,minmax(0,1fr)); gap: 16px; margin: 22px 0;}\n#thera-module .theramap-root .summary-card {background: rgba(255,255,255,.86); border: 1px solid var(--gold); border-radius: 18px; padding: 8px 14px; box-shadow: 0 10px 26px rgba(24,17,7,.06); display: flex; gap: 13px; align-items: center;}\n#thera-module .theramap-root .summary-icon {width: 32px; height: 32px; border-radius: 50%; display: grid; place-items: center; background: #f4ead7; font-size: 16px; flex: 0 0 auto;}\n#thera-module .theramap-root .summary-num {font-family: var(--font-serif); font-size: 22px; line-height: 1;}\n#thera-module .theramap-root .summary-label {color: #455066; font-size: 13px; font-weight: 800; line-height: 1.25;}\n#thera-module .theramap-root .workspace {display: grid; grid-template-columns: 285px minmax(0,1fr); gap: 22px; align-items: start;}\n#thera-module .theramap-root .panel {background: rgba(255,255,255,.88); border: 1px solid var(--line); border-radius: 22px; box-shadow: var(--shadow);}\n#thera-module .theramap-root .filters {padding: 18px; position: sticky; top: 86px;}\n#thera-module .theramap-root .panel-title {display: flex; align-items: center; justify-content: space-between; font-weight: 950; letter-spacing: .05em; text-transform: uppercase; font-size: 12px; margin-bottom: 14px;}\n#thera-module .theramap-root .reset {color: #9a6a24; background: transparent; border: 0; cursor: pointer; text-decoration: underline; font-size: 12px;}\n#thera-module .theramap-root .search {width: 100%; border: 1px solid #d9c9ad; border-radius: 12px; padding: 12px; font-size: 14px; color: var(--ink); background: rgba(255,255,255,.95); outline: none;}\n#thera-module .theramap-root .filter-group {border-top: 1px solid var(--line); padding-top: 16px; margin-top: 16px;}\n#thera-module .theramap-root .filter-heading {font-size: 12px; font-weight: 950; letter-spacing: .06em; text-transform: uppercase; margin-bottom: 12px; color: #3c465a;}\n#thera-module .theramap-root .check-row {display: flex; align-items: center; justify-content: space-between; gap: 10px; padding: 7px 0; font-size: 13px; color: #28364d;}\n#thera-module .theramap-root .check-row label {display: flex; align-items: center; gap: 8px; cursor: pointer;}\n#thera-module .theramap-root input[type=\"checkbox\"] {accent-color: #071a33;}\n#thera-module .theramap-root .count {color: #8790a3; font-weight: 850; font-size: 12px;}\n#thera-module .theramap-root .view-buttons {display: grid; gap: 8px; margin-top: 12px;}\n#thera-module .theramap-root .view-btn {border: 1px solid transparent; background: transparent; border-radius: 10px; padding: 10px 12px; text-align: left; cursor: pointer; color: #263247; font-weight: 800; display: flex; gap: 10px; align-items: center;}\n#thera-module .theramap-root .view-btn.active {border-color: #cc8f35; background: #fff7ea; color: #071a33;}\n#thera-module .theramap-root .help-card {margin-top: 16px; padding: 14px; background: #fff4dc; border: 1px solid #ead4ad; border-radius: 14px; color: #72511d; font-size: 13px; line-height: 1.45;}\n#thera-module .theramap-root .main {padding: 18px;}\n#thera-module .theramap-root .toolbar {display: flex; justify-content: space-between; gap: 14px; align-items: center; margin-bottom: 16px; color: #5f687b; font-size: 13px;}\n#thera-module .theramap-root .mode-label {font-size: 12px; text-transform: uppercase; letter-spacing: .06em; font-weight: 900; color: #7c7468;}\n#thera-module .theramap-root .lanes {display: grid; gap: 16px;}\n#thera-module .theramap-root .lane {display: grid; grid-template-columns: 230px 165px 200px minmax(360px,1fr); gap: 0; background: #fff; border: 1px solid var(--line); border-radius: 22px; overflow: hidden; box-shadow: 0 12px 26px rgba(8,19,36,.07); min-height: 138px;}\n#thera-module .theramap-root .lane.selected {outline: 4px solid rgba(177,128,53,.18); border-color: #cf9b52;}\n#thera-module .theramap-root .family-cell {padding: 14px 16px; background: radial-gradient(circle at 15% 15%, rgba(255,255,255,.70), transparent 32%),\n linear-gradient(135deg,#102b52,#071a33); color: white; display: flex; flex-direction: column; justify-content: space-between; gap: 10px; min-width: 0; overflow: visible;}\n#thera-module .theramap-root .family-kicker {font-size: 11px; text-transform: uppercase; letter-spacing: .09em; opacity: .75; font-weight: 900; margin-bottom: 8px; display: block;}\n#thera-module .theramap-root .family-title {font-family: var(--font-serif); font-size: 20px; line-height: 1.12; margin: 0; overflow-wrap: break-word; hyphens: auto;}\n#thera-module .theramap-root .family-desc {font-size: 12.5px; line-height: 1.5; overflow-wrap: break-word; hyphens: auto; color: rgba(255,255,255,.78); display: -webkit-box; -webkit-line-clamp: 3; -webkit-box-orient: vertical; overflow: hidden;}\n#thera-module .theramap-root .cell {padding: 12px 14px; border-right: 1px solid #eee2ce; display: flex; flex-direction: column; justify-content: center; gap: 8px;}\n#thera-module .theramap-root .cell:last-child {border-right: 0;}\n#thera-module .theramap-root .cell-label {font-size: 11px; text-transform: uppercase; letter-spacing: .08em; color: #7b8495; font-weight: 950;}\n#thera-module .theramap-root .target-chip {display: inline-flex; align-items: center; gap: 8px; color: #10213b; background: #f5ead8; border: 1px solid #ead8bd; border-radius: 999px; padding: 8px 10px; font-size: 13px; font-weight: 950; width: fit-content;}\n#thera-module .theramap-root .diagnostic {color: #23324d; font-size: 12.5px; line-height: 1.35; font-weight: 750;}\n#thera-module .theramap-root .therapy-list {display: grid; grid-template-columns: repeat(2,minmax(180px,1fr)); gap: 12px; align-items: start; padding: 2px 0 0; min-width: 0;}\n#thera-module .theramap-root .therapy {border: 2px solid rgba(16,33,59,.12); border-radius: 18px; padding: 11px 12px; min-width: 0; width: 100%; background: #fff; cursor: pointer; box-shadow: 0 8px 18px rgba(43,32,12,.07); transition: transform .16s ease, box-shadow .16s ease, border-color .16s ease; color: #10213b; text-align: left; position: relative;}\n#thera-module .theramap-root .therapy:hover {transform: translateY(-3px); box-shadow: 0 14px 26px rgba(43,32,12,.16); z-index: 3;}\n#thera-module .theramap-root .therapy:last-child:nth-child(odd) {grid-column: 1 / -1;}\n#thera-module .theramap-root .therapy.selected {outline: 4px solid rgba(177,128,53,.28);}\n#thera-module .theramap-root .therapy.standard {background: var(--green-soft); border-color: #72ae80;}\n#thera-module .theramap-root .therapy.research {background: var(--purple-soft); border-color: #a87bd2;}\n#thera-module .theramap-root .therapy.academic {background: var(--orange-soft); border-color: #e6a24a;}\n#thera-module .theramap-root .therapy.historic {background: var(--blue-soft); border-color: #6da7d6;}\n#thera-module .theramap-root .therapy-name {font-size: 13px; font-weight: 950; line-height: 1.2; color: #10213b;}\n#thera-module .theramap-root .therapy-brand {margin-top: 4px; font-size: 11.5px; font-weight: 850; color: #46536a;}\n#thera-module .theramap-root .status-pill {display: inline-flex; border-radius: 999px; padding: 5px 8px; font-weight: 950; font-size: 11px; margin-top: 8px; width: fit-content;}\n#thera-module .theramap-root .status-pill.standard {background: rgba(31,122,58,.12); color: var(--green);}\n#thera-module .theramap-root .status-pill.research {background: rgba(122,63,178,.12); color: var(--purple);}\n#thera-module .theramap-root .status-pill.academic {background: rgba(197,110,0,.12); color: var(--orange);}\n#thera-module .theramap-root .status-pill.historic {background: rgba(46,111,181,.12); color: var(--blue);}\n#thera-module .theramap-root .detail {margin-top: 18px; padding: 20px; background: rgba(255,255,255,.94); border: 1px solid var(--line); border-radius: 22px; box-shadow: 0 12px 30px rgba(8,19,36,.08);}\n#thera-module .theramap-root .detail-header {display: grid; grid-template-columns: 1fr 430px; gap: 20px; border-bottom: 1px solid var(--line); padding-bottom: 14px; margin-bottom: 16px; align-items: start;}\n#thera-module .theramap-root .detail h2 {font-family: var(--font-serif); margin: 0 0 8px; font-size: 30px; color: #0b1d37;}\n#thera-module .theramap-root .detail-subtitle {color: #6d7484; margin: 0; font-weight: 800;}\n#thera-module .theramap-root .explain {color: #46536a; font-size: 14px; line-height: 1.52; background: #fff8ed; border: 1px solid #ead4ad; border-radius: 14px; padding: 12px 14px;}\n#thera-module .theramap-root .detail-grid {display: grid; grid-template-columns: 1fr 1fr 1.15fr; gap: 18px;}\n#thera-module .theramap-root .detail-section {border: 1px solid #eee2ce; background: rgba(255,255,255,.74); border-radius: 14px; padding: 14px;}\n#thera-module .theramap-root .detail-section h3 {margin: 0 0 10px; font-size: 12px; text-transform: uppercase; letter-spacing: .07em; color: #34425b;}\n#thera-module .theramap-root .detail-section p,\n#thera-module .theramap-root .detail-section li {color: #22304a; font-size: 14px; line-height: 1.52; margin: 0 0 8px;}\n#thera-module .theramap-root .detail-section ul {padding-left: 18px; margin: 0;}\n#thera-module .theramap-root .badge-list {display: flex; flex-wrap: wrap; gap: 8px; margin-top: 8px;}\n#thera-module .theramap-root .badge {border: 1px solid var(--line); background: #fff8ed; color: #5d4624; border-radius: 999px; padding: 6px 9px; font-size: 12px; font-weight: 850;}\n#thera-module .theramap-root .warning {margin-top: 16px; background: #fff5df; color: #71511d; border: 1px solid #ecd3a7; padding: 12px; border-radius: 13px; font-size: 13px; line-height: 1.4;}\n#thera-module .theramap-root .table-view {display: none; width: 100%; border-collapse: separate; border-spacing: 0; overflow: hidden; border-radius: 16px; border: 1px solid var(--line); background: rgba(255,255,255,.92);}\n#thera-module .theramap-root .table-view th {background: var(--navy); color: white; text-align: left; padding: 13px 14px; font-size: 12px; text-transform: uppercase; letter-spacing: .06em;}\n#thera-module .theramap-root .table-view td {padding: 12px 14px; border-bottom: 1px solid #eee2ce; font-size: 14px; vertical-align: top; cursor: pointer;}\n#thera-module .theramap-root .table-view tr:hover td {background: #fff7ea;}\n#thera-module .theramap-root .table-view tr:last-child td {border-bottom: none;}\n#thera-module .theramap-root .hidden {display: none !important;}\n@media (max-width:1240px){#thera-module .theramap-root .hero {grid-template-columns: 1fr;}\n#thera-module .theramap-root .lane {grid-template-columns: 240px 160px 200px minmax(240px,1fr);}\n#thera-module .theramap-root .detail-header {grid-template-columns: 1fr;}\n#thera-module .theramap-root .detail-grid {grid-template-columns: 1fr 1fr;}\n}\n@media (max-width:980px){#thera-module .theramap-root .workspace {grid-template-columns: 1fr;}\n#thera-module .theramap-root .filters {position: static;}\n#thera-module .theramap-root .lane {grid-template-columns: 1fr;}\n#thera-module .theramap-root .family-cell,\n#thera-module .theramap-root .cell {border-right: 0; border-bottom: 1px solid #eee2ce;}\n#thera-module .theramap-root .cell:last-child {border-bottom: 0;}\n#thera-module .theramap-root .summary {grid-template-columns: repeat(2,minmax(0,1fr));}\n}\n@media (max-width:680px){#thera-module .theramap-root .page {padding: 22px 16px 36px;}\n#thera-module .theramap-root .legend-grid {grid-template-columns: 1fr;}\n#thera-module .theramap-root .summary {grid-template-columns: 1fr;}\n#thera-module .theramap-root .detail-grid {grid-template-columns: 1fr;}\n#thera-module .theramap-root h1 {font-size: 34px;}\n}\n#thera-sub-carte .repertoire-banner{min-height: 130px; background: linear-gradient(90deg, rgba(8,20,52,.72), rgba(8,20,52,.10)),\n linear-gradient(135deg, #0D47A1, #42A5F5); display: flex; align-items: center; color: #fff; padding: 24px 0; position: relative; overflow: hidden; border-radius: 14px; margin-bottom: 18px;}\n#thera-sub-carte .repertoire-banner::after{content: ''; position: absolute; right: 0; top: 0; bottom: 0; width: 340px; background: radial-gradient(circle at 75% 35%, rgba(255,255,255,.45), transparent 9%),\n radial-gradient(circle at 55% 60%, rgba(255,215,137,.35), transparent 8%),\n radial-gradient(circle at 90% 75%, rgba(66,165,245,.6), transparent 11%); opacity: .72; pointer-events: none;}\n#thera-sub-carte .repertoire-banner-inner{width: min(1180px, calc(100% - 48px)); margin: 0 auto; position: relative; z-index: 1;}\n#thera-sub-carte .repertoire-banner .eyebrow{color: #FFD180; text-transform: uppercase; letter-spacing: .08em; font-size: 13px; font-weight: 800; margin-bottom: 8px;}\n#thera-sub-carte .repertoire-banner h1{margin: 0; font-family: Georgia, \"Times New Roman\", serif; color: #ffffff; font-size: clamp(28px, 3vw, 44px); line-height: 1.05; letter-spacing: -.01em;}\n#thera-module .theramap-root {background: transparent; padding: 10px 0 30px; border-radius: 8px; margin-top: 6px;}\n#thera-module .theramap-root .page {max-width: 1180px; margin: 0 auto; padding: 22px 26px 30px;}\n#thera-module .theramap-root .hero {grid-template-columns: 1.05fr .95fr; gap: 22px; margin-bottom: 20px;}\n#thera-module .theramap-root .eyebrow {color: #a96c13; font-weight: 800;}\n#thera-module .theramap-root h1 {color: #081b35; font-size: clamp(28px, 3vw, 42px);}\n#thera-module .theramap-root .subtitle {color: #46536a; font-size: 14.5px;}\n#thera-module .theramap-root .legend {background: #ffffff; border: 1px solid #E0DDD7; color: #12223d; box-shadow: 0 4px 14px rgba(0,0,0,0.18);}\n#thera-module .theramap-root .legend-title {color: #0D1B2A;}\n#thera-module .theramap-root .legend-help {color: #5B7489;}\n#thera-module .theramap-root .summary {gap: 12px;}\n#thera-module .theramap-root .summary-card {background: #ffffff; border: 1px solid var(--gold); box-shadow: 0 4px 14px rgba(0,0,0,0.15);}\n#thera-module .theramap-root .workspace {gap: 18px; grid-template-columns: 240px 1fr;}\n@media (max-width: 980px){#thera-module .theramap-root .workspace {grid-template-columns: 1fr;}\n}\n#thera-module .theramap-root .panel.filters {background: #ffffff; border: 1px solid #E0DDD7; padding: 14px 14px 12px; box-shadow: 0 4px 14px rgba(0,0,0,0.15);}\n#thera-module .theramap-root .panel-title {font-size: 13px; color: #0D1B2A;}\n#thera-module .theramap-root .reset {color: #1565C0;}\n#thera-module .theramap-root .search {font-size: 13px; padding: 7px 10px;}\n#thera-module .theramap-root .filter-heading {color: #0D1B2A;}\n#thera-module .theramap-root .check-row {font-size: 12.5px;}\n#thera-module .theramap-root .help-card {background: #EAF3FA; border: 1px solid #B0CEE3; color: #0D1B2A; font-size: 12.5px;}\n#thera-module .theramap-root .help-card strong {color: #1565C0;}\n#thera-module .theramap-root .panel.main {background: #ffffff; border: 1px solid #E0DDD7; padding: 14px 14px 18px; box-shadow: 0 4px 14px rgba(0,0,0,0.15);}\n#thera-module .theramap-root .toolbar {font-size: 12.5px; color: #5B7489; padding-bottom: 8px; border-bottom: 1px solid #E0DDD7; margin-bottom: 10px;}\n#thera-module .theramap-root .mode-label {background: #EAF3FA; color: #1565C0; border-color: #B0CEE3;}\n#thera-module .theramap-root .lane {grid-template-columns: 230px 165px 200px minmax(360px, 1fr); gap: 0; min-height: 138px;}\n@media (max-width: 1100px){#thera-module .theramap-root .lane {grid-template-columns: 210px 145px 180px minmax(320px,1fr);}\n}\n@media (max-width: 900px){#thera-module .theramap-root .lane {grid-template-columns: 1fr;}\n#thera-module .theramap-root .therapy-list {grid-template-columns: 1fr;}\n}\n#thera-module .theramap-root .family-cell {padding: 14px 14px; min-width: 0;}\n#thera-module .theramap-root .family-title {font-size: 18px; word-wrap: break-word;}\n#thera-module .theramap-root .family-desc {font-size: 12px; line-height: 1.5;}\n#thera-module .theramap-root .cell {padding: 12px 14px; min-width: 0;}\n#thera-module .theramap-root .cell-label {font-size: 10.5px;}\n#thera-module .theramap-root .target-chip {font-size: 12px; padding: 4px 9px;}\n#thera-module .theramap-root .diagnostic {font-size: 12px; line-height: 1.45;}\n#thera-module .theramap-root .therapy-list {display: grid; grid-template-columns: repeat(2, minmax(170px, 1fr)); gap: 12px; align-items: start; min-width: 0;}\n#thera-module .theramap-root .therapy {padding: 10px 12px; min-width: 0; width: 100%; border-radius: 18px;}\n#thera-module .theramap-root .therapy:last-child:nth-child(odd) {grid-column: 1 / -1;}\n#thera-module .theramap-root .therapy-name {font-size: 12.5px; word-break: break-word; line-height: 1.35;}\n#thera-module .theramap-root .therapy-brand {font-size: 11px; word-break: break-word; white-space: normal; line-height: 1.4; margin-top: 3px;}\n#thera-module .theramap-root .status-pill {font-size: 10.5px; padding: 2px 7px; margin-top: 5px; display: inline-block;}\n#thera-module .theramap-root .detail {background: #ffffff; border: 1px solid #E0DDD7; margin-top: 16px; padding: 18px 20px;}\n#thera-module .theramap-root .detail h2 {color: #0D1B2A; font-size: 22px;}\n#thera-module .theramap-root .detail-subtitle {color: #5B7489; font-size: 13.5px;}\n#thera-module .theramap-root .explain {background: #EAF3FA; color: #0D1B2A; font-size: 12.5px; border: 1px solid #B0CEE3;}\n#thera-module .theramap-root .detail-section h3 {color: #0D1B2A; font-size: 14px;}\n#thera-module .theramap-root .badge {background: #EAF3FA; color: #1565C0;}\n#thera-module .theramap-root .warning {background: #FFF4E5; border-left-color: #FF6F00; color: #5B4631; font-size: 12px;}\n#thera-module .theramap-root .footer-note {color: #9EC2DC !important;}\n#thera-module .theramap-root .page {max-width: 1280px !important; width: 100% !important; margin: 0 auto !important; padding-left: 32px !important; padding-right: 32px !important;}\n#thera-module .theramap-root .workspace {grid-template-columns: 250px minmax(0, 1fr) !important; gap: 18px !important;}\n#thera-module .theramap-root .panel.main {overflow: visible !important; min-width: 0 !important;}\n#thera-module .theramap-root .lanes {min-width: 0 !important;}\n#thera-module .theramap-root .lane {overflow: visible !important; grid-template-columns: minmax(200px, 230px) minmax(135px, 165px) minmax(170px, 200px) minmax(340px, 1fr) !important; min-width: 0 !important;}\n#thera-module .theramap-root .cell {min-width: 0 !important;}\n#thera-module .theramap-root .therapy-list {grid-template-columns: repeat(2, minmax(145px, 1fr)) !important; gap: 12px !important; min-width: 0 !important;}\n#thera-module .theramap-root .therapy {min-width: 0 !important; max-width: 100% !important;}\n#thera-module .theramap-root .therapy-name,\n#thera-module .theramap-root .therapy-brand {overflow-wrap: anywhere !important; word-break: normal !important;}\n@media (max-width: 1180px){#thera-module .theramap-root .page {padding-left: 20px !important; padding-right: 20px !important;}\n#thera-module .theramap-root .workspace {grid-template-columns: 230px minmax(0, 1fr) !important; gap: 14px !important;}\n#thera-module .theramap-root .lane {grid-template-columns: minmax(180px, 210px) minmax(120px, 145px) minmax(145px, 175px) minmax(285px, 1fr) !important;}\n#thera-module .theramap-root .therapy-list {grid-template-columns: repeat(2, minmax(125px, 1fr)) !important; gap: 10px !important;}\n#thera-module .theramap-root .therapy-name {font-size: 12px !important;}\n#thera-module .theramap-root .therapy-brand {font-size: 10.5px !important;}\n#thera-module .theramap-root .family-title {font-size: 17px !important;}\n}\n@media (max-width: 980px){#thera-module .theramap-root .workspace {grid-template-columns: 1fr !important;}\n#thera-module .theramap-root .filters {position: static !important;}\n#thera-module .theramap-root .lane {grid-template-columns: 1fr !important; overflow: hidden !important;}\n#thera-module .theramap-root .therapy-list {grid-template-columns: repeat(2, minmax(150px, 1fr)) !important;}\n}\n@media (max-width: 620px){#thera-module .theramap-root .therapy-list {grid-template-columns: 1fr !important;}\n}\n\n\n#page-theranostique #thera-module .thera-subtabs{width: 100% !important; margin-left: 0 !important; margin-right: 0 !important;}\n#page-theranostique #thera-module .theramap-root .page{margin-left: auto !important; margin-right: auto !important;}\n\n\n\n\n\n\n\n\n","html":"
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Theranostics
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Clinical map of theranostic therapies

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☝️ Click on a therapeutic agent to open its sheet below.
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Separate therapeutic cards
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Standard clinique
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Select an agent

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The detailed sheet will appear here.

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This representation is deliberately clinical: the tissue or context is prioritised, the molecular target is explained separately.
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Therapeutic agent

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Associated imaging

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Key indications

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Validation notes

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Visual prototype: regulatory labels must be adapted country by country before publication. Research agents are deliberately separated from agents with MA/CE or established clinical use.
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Nucleascope — alternative UX prototype. Information is structured to support navigation and does not replace SmPCs, leaflets, national recommendations or local reimbursement decisions.
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","ui":{"status_standard":"Clinical standard","status_research":"Research / trials","status_academic":"Academic / variable access","status_historic":"Historical standard","status_text_standard":"Therapy with MA / robust clinical use or well-established CE device in the indicated setting.","status_text_research":"Approach evaluated in trials or academic programs; not a routine standard.","status_text_academic":"Variable access across centers/countries, often academic, compassionate or historical.","status_text_historic":"Long-standing clinical use, often with variable national availability and brand names.","cell_target":"Target / mechanism","cell_imaging":"Selection imaging","cell_agents":"Therapeutic agents","brand_variable":"variable / non-standardized brand name","detail_status_prefix":"Status:","detail_brand_prefix":"Brand name:"},"families":[{"id":"net","icon":"NET","family":"Neuroendocrine tumours","target":"SSTR","mechanism":"Somatostatin receptors","diagnostic":"PET ⁶⁸Ga-DOTA-SSA depending on availability","description":"Clinical context: SSTR-positive neuroendocrine tumours. Lutetium, yttrium, copper or terbium designate the therapeutic agent, not the target."},{"id":"prostate","icon":"PCA","family":"Prostate cancer","target":"PSMA","mechanism":"Prostate-specific membrane antigen","diagnostic":"PET PSMA: ⁶⁸Ga-PSMA-11 or ¹⁸F-PSMA depending on availability","description":"Clinical context: PSMA-positive prostate cancer. PSMA is a molecular target distinct from SSTR."},{"id":"stroma","icon":"FAP","family":"Tumour stroma","target":"FAP / FAPI","mechanism":"Fibroblast activation protein","diagnostic":"PET FAPI, according to protocol or trial","description":"Broad clinical context: solid tumours with FAP-rich stroma. Status predominantly research."},{"id":"grpr","icon":"GRPR","family":"Breast / prostate exploratory","target":"GRPR","mechanism":"Bombesin receptor","diagnostic":"PET ⁶⁸Ga-RM2 or ⁶⁸Ga-NeoBOMB1 according to protocol","description":"Exploratory family: GRPR-expressing tumours, notably certain breast/prostate indications."},{"id":"mibg","icon":"MIBG","family":"Phaeochromocytoma / paraganglioma / neuroblastoma","target":"Transport noradrénergique","mechanism":"MIBG","diagnostic":"Scintigraphy/SPECT ¹²³I-MIBG","description":"Historical scintigraphy/SPECT-therapy pair, with variable national availability."},{"id":"thyroid","icon":"THY","family":"Thyroid","target":"NIS","mechanism":"Sodium-iodide symporter","diagnostic":"¹²³I or ¹³¹I diagnostic according to indication","description":"Thyroid clinical context: hyperthyroidism and differentiated cancers taking up iodine."},{"id":"hematology","icon":"CXCR4","family":"Haematology / CXCR4+ tumours","target":"CXCR4","mechanism":"Chemokine receptor","diagnostic":"PET ⁶⁸Ga-pentixafor","description":"Research family or specialised academic programmes."},{"id":"bone","icon":"OS","family":"Bone metastases","target":"Tropisme osseux","mechanism":"Osteoblastic metastases","diagnostic":"Bone scintigraphy / bone imaging according to context","description":"Clinical context: osteoblastic bone metastases of castration-resistant prostate cancer."},{"id":"liver","icon":"FOIE","family":"Liver","target":"Territoire hépatique","mechanism":"Intra-arterial radioembolisation","diagnostic":"Simulation ⁹⁹ᵐTc-MAA SPECT/CT or device-specific scout","description":"Clinical context: primary or secondary liver tumours; procedural and dosimetric logic."}],"agents":[{"id":"lutathera","family":"net","status":"standard","name":"¹⁷⁷Lu-oxodotreotide","commercial":"Lutathera®","diagnostic":"PET ⁶⁸Ga-DOTA-SSA depending on availability","indications":["Well-differentiated GEP-NET SSTR+","Unresectable or metastatic, progressive disease per current European indication"],"notes":"EMA standard agent for SSTR+ GEP-NETs. Keep indication extensions separate.","tags":["EMA marketing authorisation","PRRT","SSTR"]},{"id":"y90-dotatoc","family":"net","status":"academic","name":"⁹⁰Y-DOTATOC / ⁹⁰Y-DOTATATE","commercial":"—","diagnostic":"PET ⁶⁸Ga-DOTA-SSA","indications":["Historical/academic SSTR+ approaches"],"notes":"Variable access and standardisation; do not present as regulatory equivalent to Lutathera®.","tags":["Variable access","SSTR"]},{"id":"cu67-sartate","family":"net","status":"research","name":"⁶⁷Cu-SARTATE","commercial":"—","diagnostic":"⁶⁴Cu-DOTATATE / ⁶⁴Cu-SARTATE per protocol","indications":["Clinical research SSTR+"],"notes":"Research; not European routine clinical standard.","tags":["Research","Cu-67"]},{"id":"tb161-sstr","family":"net","status":"research","name":"¹⁶¹Tb-DOTATOC / ¹⁶¹Tb-DOTATATE","commercial":"—","diagnostic":"Analogous SSTR vectors per protocol","indications":["Research SSTR+"],"notes":"Research; limited availability.","tags":["Research","Tb-161"]},{"id":"pluvicto","family":"prostate","status":"standard","name":"¹⁷⁷Lu-vipivotide tetraxetan","commercial":"Pluvicto®","diagnostic":"PET PSMA: ⁶⁸Ga-PSMA-11 or ¹⁸F-PSMA depending on availability","indications":["mCRPC PSMA+","After ARPI and taxane per current European indication"],"notes":"EMA marketing authorisation. The European pre-taxane extension should not be presented as validated following the withdrawal of the variation in April 2026.","tags":["EMA marketing authorisation","PSMA","mCRPC"]},{"id":"psma-it","family":"prostate","status":"academic","name":"¹⁷⁷Lu-PSMA-I&T","commercial":"—","diagnostic":"PET PSMA","indications":["Academic use, trials or local access PSMA+"],"notes":"Different PSMA vector; variable regulatory status.","tags":["Variable access","PSMA"]},{"id":"ac225-psma","family":"prostate","status":"research","name":"²²⁵Ac-PSMA-617","commercial":"—","diagnostic":"PET PSMA","indications":["Alpha-therapy approaches in expert centres or trials"],"notes":"Research/compassionate; consider toxicity and availability of ²²⁵Ac.","tags":["Alpha","Research"]},{"id":"tb161-psma","family":"prostate","status":"research","name":"¹⁶¹Tb-PSMA","commercial":"—","diagnostic":"PET PSMA","indications":["Research PSMA+"],"notes":"Research; not a regulatory equivalent to Pluvicto®.","tags":["Research","Tb-161"]},{"id":"lu177-fapi","family":"stroma","status":"research","name":"¹⁷⁷Lu-FAPI","commercial":"—","diagnostic":"PET FAPI","indications":["FAP-rich solid tumours per trials"],"notes":"No routine EMA authorisation; research or expert access.","tags":["FAP","Research"]},{"id":"y90-fapi","family":"stroma","status":"research","name":"⁹⁰Y-FAPI","commercial":"—","diagnostic":"PET FAPI","indications":["Early research"],"notes":"Limited data.","tags":["Research"]},{"id":"ac225-fapi","family":"stroma","status":"research","name":"²²⁵Ac-FAPI","commercial":"—","diagnostic":"PET FAPI","indications":["Research alpha-therapy FAP"],"notes":"To be presented as experimental.","tags":["Alpha","Research"]},{"id":"lu177-rm2","family":"grpr","status":"research","name":"¹⁷⁷Lu-RM2","commercial":"—","diagnostic":"PET ⁶⁸Ga-RM2 / ⁶⁸Ga-NeoBOMB1","indications":["GRPR+ tumours per trials"],"notes":"Early studies; research status.","tags":["GRPR","Research"]},{"id":"i131-mibg","family":"mibg","status":"historic","name":"¹³¹I-iobenguane / ¹³¹I-MIBG","commercial":"noms nationaux variables","diagnostic":"¹²³I-MIBG SPECT","indications":["MIBG+ PPGL","MIBG+ neuroblastoma per protocols"],"notes":"Availability and regulatory framework vary by country.","tags":["Historical","MIBG"]},{"id":"i131-nai","family":"thyroid","status":"historic","name":"¹³¹I-iodure de sodium","commercial":"noms nationaux variables","diagnostic":"¹²³I or ¹³¹I diagnostic depending on indication","indications":["Hyperthyroidism","Iodine-avid differentiated thyroid cancer"],"notes":"Historical and standard treatment, with variable national products and labelling.","tags":["Iodine","NIS"]},{"id":"pentixather","family":"hematology","status":"research","name":"¹⁷⁷Lu-pentixather / ⁹⁰Y-pentixather","commercial":"—","diagnostic":"PET ⁶⁸Ga-pentixafor","indications":["Haematology and CXCR4+ tumours in specialised programmes"],"notes":"Research / academic; not routine standard.","tags":["CXCR4","Research"]},{"id":"xofigo","family":"bone","status":"standard","name":"²²³Ra-dichloride","commercial":"Xofigo®","diagnostic":"Bone scintigraphy / bone imaging according to context","indications":["mCRPC with symptomatic bone metastases","No known visceral metastases, per European indication"],"notes":"Bone-tropic alpha emitter; not a strict PET ligand-receptor pair.","tags":["EMA marketing authorisation","Alpha","Bone"]},{"id":"sir-spheres","family":"liver","status":"standard","name":"⁹⁰Y resin microspheres","commercial":"SIR-Spheres®","diagnostic":"⁹⁹ᵐTc-MAA SPECT/CT + post-therapy imaging","indications":["Unresectable HCC","Selected liver metastases per local/CE indication"],"notes":"Radioembolisation device; procedural and dosimetric logic.","tags":["CE","Liver","Radioembolisation"]},{"id":"therasphere","family":"liver","status":"standard","name":"⁹⁰Y glass microspheres","commercial":"TheraSphere™","diagnostic":"⁹⁹ᵐTc-MAA SPECT/CT + post-therapy imaging","indications":["Selected hepatic malignancies"],"notes":"CE-marked device for the treatment of hepatic neoplasms; exact indications per jurisdiction.","tags":["CE","Liver","Radioembolisation"]},{"id":"quirem","family":"liver","status":"standard","name":"¹⁶⁶Ho microspheres","commercial":"QuiremSpheres®","diagnostic":"⁹⁹ᵐTc-MAA or holmium scout per protocol + holmium imaging","indications":["Selected hepatic tumours"],"notes":"Holmium-166 microspheres CE; availability and protocol per centre/country.","tags":["CE","Ho-166","Liver"]}]},"animation":{"css":"\n :host {\n --gold:#ffd54a;\n --orange:#ff8a00;\n --hot:#fff3a0;\n --navy:#0b1d3a;\n }\n * { box-sizing:border-box; }\n .source-body {\n margin:0;\n min-height:100vh;\n display:flex;\n align-items:center;\n justify-content:center;\n background: radial-gradient(circle at center, #ffffff 0%, #eef3f7 72%, #dfe8ef 100%);\n font-family: -apple-system, BlinkMacSystemFont, \"Segoe UI\", Roboto, Arial, sans-serif;\n color:var(--navy);\n overflow:hidden;\n }\n .wrap {\n position:relative;\n width:min(95vw, 590px);\n aspect-ratio: 9 / 16;\n border-radius:28px;\n overflow:hidden;\n box-shadow: 0 25px 70px rgba(10,30,60,.20);\n background:white;\n }\n .frame {\n position:absolute;\n inset:0;\n width:100%;\n height:100%;\n object-fit:cover;\n opacity:0;\n animation: frameCycle 12s infinite ease-in-out;\n }\n .frame:nth-child(1) { animation-delay:0s; }\n .frame:nth-child(2) { animation-delay:3s; }\n .frame:nth-child(3) { animation-delay:6s; }\n .frame:nth-child(4) { animation-delay:9s; }\n @keyframes frameCycle {\n 0% { opacity:0; transform:scale(1.015); filter:saturate(1.02); }\n 8% { opacity:1; }\n 22% { opacity:1; transform:scale(1.0); filter:saturate(1.10); }\n 30% { opacity:0; transform:scale(1.01); filter:saturate(1.18); }\n 100% { opacity:0; }\n }\n .vignette {\n position:absolute; inset:0;\n background: linear-gradient(180deg, rgba(255,255,255,.12) 0%, rgba(255,255,255,0) 24%, rgba(5,25,55,.08) 100%);\n pointer-events:none;\n }\n\n @keyframes progress { from { transform:scaleX(0); } to { transform:scaleX(1); } }\n\n\n .spark {\n position:absolute; width:10px; height:10px; border-radius:50%;\n background: radial-gradient(circle, #fff 0%, #ffe76b 32%, #ff8a00 70%, rgba(255,138,0,0) 100%);\n box-shadow:0 0 14px #ffb300,0 0 28px rgba(255,145,0,.8);\n opacity:0;\n animation: sparkPath 12s infinite ease-in-out;\n }\n .spark.s1 { left:9%; top:65%; animation-delay:.2s; }\n .spark.s2 { left:19%; top:56%; animation-delay:.45s; transform:scale(.75); }\n .spark.s3 { left:44%; top:68%; animation-delay:.9s; transform:scale(.9); }\n .spark.s4 { left:52%; top:54%; animation-delay:1.4s; transform:scale(.72); }\n .spark.s5 { left:57%; top:75%; animation-delay:2.2s; transform:scale(1.1); }\n @keyframes sparkPath {\n 0%,6% { opacity:0; filter:blur(0); }\n 8% { opacity:1; }\n 18% { transform:translate(60px,-160px) scale(.8); opacity:1; }\n 34% { transform:translate(200px,-230px) scale(.9); opacity:.9; }\n 48% { transform:translate(230px,-80px) scale(1.1); opacity:.85; }\n 66% { transform:translate(240px,40px) scale(1.2); opacity:.75; }\n 84% { transform:translate(260px,90px) scale(1.55); opacity:.55; }\n 100% { opacity:0; transform:translate(270px,115px) scale(1.7); }\n }\n .pulse {\n position:absolute; border-radius:50%; opacity:.0;\n background: radial-gradient(circle, rgba(255,255,255,.95) 0%, rgba(255,231,85,.85) 24%, rgba(255,138,0,.35) 55%, rgba(255,138,0,0) 75%);\n animation:pulse 12s infinite ease-in-out;\n mix-blend-mode:screen;\n }\n .prostate { width:86px; height:86px; left:43.5%; top:72.5%; animation-delay:6s; }\n .pelvisL { width:88px; height:88px; left:31%; top:66%; animation-delay:6.2s; }\n .pelvisR { width:88px; height:88px; left:57%; top:66%; animation-delay:6.35s; }\n .spine { width:70px; height:170px; left:46.5%; top:41%; animation-delay:6.5s; border-radius:45%; }\n .ribs { width:95px; height:95px; left:61%; top:30.5%; animation-delay:6.8s; }\n @keyframes pulse {\n 0%,45% { opacity:0; transform:scale(.35); }\n 50% { opacity:.55; transform:scale(.8); }\n 65% { opacity:.95; transform:scale(1.15); }\n 80% { opacity:.55; transform:scale(1.35); }\n 100% { opacity:0; transform:scale(1.65); }\n }\n\n","html":"
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"},"tabsCSS":"\n\n\n\n#thera-module .thera-subtabs {display: flex; gap: 8px; margin: 0 0 14px; padding: 8px 0 0 0; padding-bottom: 2px; border-bottom: 2px solid #E0DDD7; position: sticky; top: 60px; background: #fffaf0; z-index: 30;}\n#thera-module .thera-subtab {background: transparent; border: none; padding: 10px 20px; font-family: Georgia,\"Times New Roman\",serif; font-size: 15px; font-weight: 600; color: #647086; cursor: pointer; transition: all .2s; border-radius: 8px 8px 0 0; margin-bottom: -2px; border-bottom: 2px solid transparent; display: inline-flex; align-items: center; gap: 7px;}\n#thera-module .thera-subtab:hover {background: rgba(13,27,42,.06); color: #0D1B2A;}\n#thera-module .thera-subtab.active {color: #0D1B2A; background: #fffaf0; border-bottom-color: #1565C0; font-weight: 700;}\n#thera-module .thera-subtab[data-thera-subtab=\"partner\"]{background: #FFE8C7; color: #0D1B2A !important; border: 1px solid #FFB060; border-radius: 8px; margin: 0 4px; padding: 9px 16px; font-weight: 700; box-shadow: 0 1px 3px rgba(230,81,0,.12);}\n#thera-module .thera-subtab[data-thera-subtab=\"partner\"]:hover{background: #FFD9A3; border-color: #FF9800; box-shadow: 0 2px 6px rgba(230,81,0,.2); color: #0D1B2A;}\n#thera-module .thera-subtab[data-thera-subtab=\"partner\"].active{background: #FFD9A3; border-color: #FF9800; border-bottom-color: #FF9800; box-shadow: 0 2px 6px rgba(230,81,0,.2);}\n#thera-module .theramap-root {--navy: #071a33; --navy2: #0d2a50; --ink: #12223d; --muted: #647086; --paper: #fffaf0; --card: #ffffff; --soft: #f8efe0; --line: #e5d6bf; --gold: #b18035; --green: #1f7a3a; --green-soft: #ecf8ef; --purple: #7a3fb2; --purple-soft: #f5ecfb; --orange: #c56e00; --orange-soft: #fff1dc; --blue: #2e6fb5; --blue-soft: #edf6ff; --red: #b84a42; --shadow: 0 18px 45px rgba(8,19,36,.10); --font-serif: Georgia,\"Times New Roman\",serif; --font-sans: Inter,ui-sans-serif,system-ui,-apple-system,BlinkMacSystemFont,\"Segoe UI\",sans-serif; color: var(--ink); font-family: var(--font-sans); background: radial-gradient(circle at 85% 5%, rgba(255,255,255,.96), transparent 32%),\n radial-gradient(circle at 10% 50%, rgba(239,220,185,.78), transparent 46%),\n linear-gradient(135deg,#fffaf0,#f2e3c6); border-radius: 18px; padding: 6px 0 12px; margin-top: 8px;}\n#thera-module .theramap-root .page {max-width: 100%; width: 100%; margin: 0; padding: 36px 36px 46px; background: transparent; border-radius: 18px; color: var(--ink);}\n#thera-module .theramap-root .hero {display: grid; grid-template-columns: 1.1fr .9fr; gap: 28px; align-items: end; margin-bottom: 22px;}\n#thera-module .theramap-root .eyebrow {color: #a96c13; text-transform: uppercase; letter-spacing: .08em; font-size: 13px; font-weight: 900; margin-bottom: 8px;}\n#thera-module .theramap-root h1 {margin: 0 0 12px; font-family: var(--font-serif); font-size: clamp(34px,4vw,54px); line-height: .98; color: #081b35; letter-spacing: -.02em;}\n#thera-module .theramap-root .subtitle {max-width: 820px; margin: 0; color: #46536a; font-size: 15px; line-height: 1.6;}\n#thera-module .theramap-root .legend {background: rgba(255,255,255,.80); border: 1px solid var(--line); border-radius: 20px; padding: 16px 18px; box-shadow: 0 10px 25px rgba(36,23,5,.06);}\n#thera-module .theramap-root .legend-title {font-size: 12px; font-weight: 950; letter-spacing: .08em; text-transform: uppercase; color: #34425b; margin-bottom: 12px;}\n#thera-module .theramap-root .legend-grid {display: grid; grid-template-columns: repeat(2,minmax(0,1fr)); gap: 10px 14px; font-size: 13px; font-weight: 850;}\n#thera-module .theramap-root .dot {width: 12px; height: 12px; border-radius: 50%; display: inline-block; margin-right: 8px; vertical-align: -1px;}\n#thera-module .theramap-root .dot.standard {background: var(--green);}\n#thera-module .theramap-root .dot.research {background: var(--purple);}\n#thera-module .theramap-root .dot.academic {background: var(--orange);}\n#thera-module .theramap-root .dot.historic {background: var(--blue);}\n#thera-module .theramap-root .legend-help {margin-top: 12px; padding-top: 12px; border-top: 1px dashed #d8c6a8; color: #5c6678; font-size: 12.5px; line-height: 1.45;}\n#thera-module .theramap-root .summary {display: grid; grid-template-columns: repeat(4,minmax(0,1fr)); gap: 16px; margin: 22px 0;}\n#thera-module .theramap-root .summary-card {background: rgba(255,255,255,.86); border: 1px solid var(--gold); border-radius: 18px; padding: 8px 14px; box-shadow: 0 10px 26px rgba(24,17,7,.06); display: flex; gap: 13px; align-items: center;}\n#thera-module .theramap-root .summary-icon {width: 32px; height: 32px; border-radius: 50%; display: grid; place-items: center; background: #f4ead7; font-size: 16px; flex: 0 0 auto;}\n#thera-module .theramap-root .summary-num {font-family: var(--font-serif); font-size: 22px; line-height: 1;}\n#thera-module .theramap-root .summary-label {color: #455066; font-size: 13px; font-weight: 800; line-height: 1.25;}\n#thera-module .theramap-root .workspace {display: grid; grid-template-columns: 285px minmax(0,1fr); gap: 22px; align-items: start;}\n#thera-module .theramap-root .panel {background: rgba(255,255,255,.88); border: 1px solid var(--line); border-radius: 22px; box-shadow: var(--shadow);}\n#thera-module .theramap-root .filters {padding: 18px; position: sticky; top: 86px;}\n#thera-module .theramap-root .panel-title {display: flex; align-items: center; justify-content: space-between; font-weight: 950; letter-spacing: .05em; text-transform: uppercase; font-size: 12px; margin-bottom: 14px;}\n#thera-module .theramap-root .reset {color: #9a6a24; background: transparent; border: 0; cursor: pointer; text-decoration: underline; font-size: 12px;}\n#thera-module .theramap-root .search {width: 100%; border: 1px solid #d9c9ad; border-radius: 12px; padding: 12px; font-size: 14px; color: var(--ink); background: rgba(255,255,255,.95); outline: none;}\n#thera-module .theramap-root .filter-group {border-top: 1px solid var(--line); padding-top: 16px; margin-top: 16px;}\n#thera-module .theramap-root .filter-heading {font-size: 12px; font-weight: 950; letter-spacing: .06em; text-transform: uppercase; margin-bottom: 12px; color: #3c465a;}\n#thera-module .theramap-root .check-row {display: flex; align-items: center; justify-content: space-between; gap: 10px; padding: 7px 0; font-size: 13px; color: #28364d;}\n#thera-module .theramap-root .check-row label {display: flex; align-items: center; gap: 8px; cursor: pointer;}\n#thera-module .theramap-root input[type=\"checkbox\"] {accent-color: #071a33;}\n#thera-module .theramap-root .count {color: #8790a3; font-weight: 850; font-size: 12px;}\n#thera-module .theramap-root .view-buttons {display: grid; gap: 8px; margin-top: 12px;}\n#thera-module .theramap-root .view-btn {border: 1px solid transparent; background: transparent; border-radius: 10px; padding: 10px 12px; text-align: left; cursor: pointer; color: #263247; font-weight: 800; display: flex; gap: 10px; align-items: center;}\n#thera-module .theramap-root .view-btn.active {border-color: #cc8f35; background: #fff7ea; color: #071a33;}\n#thera-module .theramap-root .help-card {margin-top: 16px; padding: 14px; background: #fff4dc; border: 1px solid #ead4ad; border-radius: 14px; color: #72511d; font-size: 13px; line-height: 1.45;}\n#thera-module .theramap-root .main {padding: 18px;}\n#thera-module .theramap-root .toolbar {display: flex; justify-content: space-between; gap: 14px; align-items: center; margin-bottom: 16px; color: #5f687b; font-size: 13px;}\n#thera-module .theramap-root .mode-label {font-size: 12px; text-transform: uppercase; letter-spacing: .06em; font-weight: 900; color: #7c7468;}\n#thera-module .theramap-root .lanes {display: grid; gap: 16px;}\n#thera-module .theramap-root .lane {display: grid; grid-template-columns: 230px 165px 200px minmax(360px,1fr); gap: 0; background: #fff; border: 1px solid var(--line); border-radius: 22px; overflow: hidden; box-shadow: 0 12px 26px rgba(8,19,36,.07); min-height: 138px;}\n#thera-module .theramap-root .lane.selected {outline: 4px solid rgba(177,128,53,.18); border-color: #cf9b52;}\n#thera-module .theramap-root .family-cell {padding: 14px 16px; background: radial-gradient(circle at 15% 15%, rgba(255,255,255,.70), transparent 32%),\n linear-gradient(135deg,#102b52,#071a33); color: white; display: flex; flex-direction: column; justify-content: space-between; gap: 10px; min-width: 0; overflow: visible;}\n#thera-module .theramap-root .family-kicker {font-size: 11px; text-transform: uppercase; letter-spacing: .09em; opacity: .75; font-weight: 900; margin-bottom: 8px; display: block;}\n#thera-module .theramap-root .family-title {font-family: var(--font-serif); font-size: 20px; line-height: 1.12; margin: 0; overflow-wrap: break-word; hyphens: auto;}\n#thera-module .theramap-root .family-desc {font-size: 12.5px; line-height: 1.5; overflow-wrap: break-word; hyphens: auto; color: rgba(255,255,255,.78); display: -webkit-box; -webkit-line-clamp: 3; -webkit-box-orient: vertical; overflow: hidden;}\n#thera-module .theramap-root .cell {padding: 12px 14px; border-right: 1px solid #eee2ce; display: flex; flex-direction: column; justify-content: center; gap: 8px;}\n#thera-module .theramap-root .cell:last-child {border-right: 0;}\n#thera-module .theramap-root .cell-label {font-size: 11px; text-transform: uppercase; letter-spacing: .08em; color: #7b8495; font-weight: 950;}\n#thera-module .theramap-root .target-chip {display: inline-flex; align-items: center; gap: 8px; color: #10213b; background: #f5ead8; border: 1px solid #ead8bd; border-radius: 999px; padding: 8px 10px; font-size: 13px; font-weight: 950; width: fit-content;}\n#thera-module .theramap-root .diagnostic {color: #23324d; font-size: 12.5px; line-height: 1.35; font-weight: 750;}\n#thera-module .theramap-root .therapy-list {display: grid; grid-template-columns: repeat(2,minmax(180px,1fr)); gap: 12px; align-items: start; padding: 2px 0 0; min-width: 0;}\n#thera-module .theramap-root .therapy {border: 2px solid rgba(16,33,59,.12); border-radius: 18px; padding: 11px 12px; min-width: 0; width: 100%; background: #fff; cursor: pointer; box-shadow: 0 8px 18px rgba(43,32,12,.07); transition: transform .16s ease, box-shadow .16s ease, border-color .16s ease; color: #10213b; text-align: left; position: relative;}\n#thera-module .theramap-root .therapy:hover {transform: translateY(-3px); box-shadow: 0 14px 26px rgba(43,32,12,.16); z-index: 3;}\n#thera-module .theramap-root .therapy:last-child:nth-child(odd) {grid-column: 1 / -1;}\n#thera-module .theramap-root .therapy.selected {outline: 4px solid rgba(177,128,53,.28);}\n#thera-module .theramap-root .therapy.standard {background: var(--green-soft); border-color: #72ae80;}\n#thera-module .theramap-root .therapy.research {background: var(--purple-soft); border-color: #a87bd2;}\n#thera-module .theramap-root .therapy.academic {background: var(--orange-soft); border-color: #e6a24a;}\n#thera-module .theramap-root .therapy.historic {background: var(--blue-soft); border-color: #6da7d6;}\n#thera-module .theramap-root .therapy-name {font-size: 13px; font-weight: 950; line-height: 1.2; color: #10213b;}\n#thera-module .theramap-root .therapy-brand {margin-top: 4px; font-size: 11.5px; font-weight: 850; color: #46536a;}\n#thera-module .theramap-root .status-pill {display: inline-flex; border-radius: 999px; padding: 5px 8px; font-weight: 950; font-size: 11px; margin-top: 8px; width: fit-content;}\n#thera-module .theramap-root .status-pill.standard {background: rgba(31,122,58,.12); color: var(--green);}\n#thera-module .theramap-root .status-pill.research {background: rgba(122,63,178,.12); color: var(--purple);}\n#thera-module .theramap-root .status-pill.academic {background: rgba(197,110,0,.12); color: var(--orange);}\n#thera-module .theramap-root .status-pill.historic {background: rgba(46,111,181,.12); color: var(--blue);}\n#thera-module .theramap-root .detail {margin-top: 18px; padding: 20px; background: rgba(255,255,255,.94); border: 1px solid var(--line); border-radius: 22px; box-shadow: 0 12px 30px rgba(8,19,36,.08);}\n#thera-module .theramap-root .detail-header {display: grid; grid-template-columns: 1fr 430px; gap: 20px; border-bottom: 1px solid var(--line); padding-bottom: 14px; margin-bottom: 16px; align-items: start;}\n#thera-module .theramap-root .detail h2 {font-family: var(--font-serif); margin: 0 0 8px; font-size: 30px; color: #0b1d37;}\n#thera-module .theramap-root .detail-subtitle {color: #6d7484; margin: 0; font-weight: 800;}\n#thera-module .theramap-root .explain {color: #46536a; font-size: 14px; line-height: 1.52; background: #fff8ed; border: 1px solid #ead4ad; border-radius: 14px; padding: 12px 14px;}\n#thera-module .theramap-root .detail-grid {display: grid; grid-template-columns: 1fr 1fr 1.15fr; gap: 18px;}\n#thera-module .theramap-root .detail-section {border: 1px solid #eee2ce; background: rgba(255,255,255,.74); border-radius: 14px; padding: 14px;}\n#thera-module .theramap-root .detail-section h3 {margin: 0 0 10px; font-size: 12px; text-transform: uppercase; letter-spacing: .07em; color: #34425b;}\n#thera-module .theramap-root .detail-section p,\n#thera-module .theramap-root .detail-section li {color: #22304a; font-size: 14px; line-height: 1.52; margin: 0 0 8px;}\n#thera-module .theramap-root .detail-section ul {padding-left: 18px; margin: 0;}\n#thera-module .theramap-root .badge-list {display: flex; flex-wrap: wrap; gap: 8px; margin-top: 8px;}\n#thera-module .theramap-root .badge {border: 1px solid var(--line); background: #fff8ed; color: #5d4624; border-radius: 999px; padding: 6px 9px; font-size: 12px; font-weight: 850;}\n#thera-module .theramap-root .warning {margin-top: 16px; background: #fff5df; color: #71511d; border: 1px solid #ecd3a7; padding: 12px; border-radius: 13px; font-size: 13px; line-height: 1.4;}\n#thera-module .theramap-root .table-view {display: none; width: 100%; border-collapse: separate; border-spacing: 0; overflow: hidden; border-radius: 16px; border: 1px solid var(--line); background: rgba(255,255,255,.92);}\n#thera-module .theramap-root .table-view th {background: var(--navy); color: white; text-align: left; padding: 13px 14px; font-size: 12px; text-transform: uppercase; letter-spacing: .06em;}\n#thera-module .theramap-root .table-view td {padding: 12px 14px; border-bottom: 1px solid #eee2ce; font-size: 14px; vertical-align: top; cursor: pointer;}\n#thera-module .theramap-root .table-view tr:hover td {background: #fff7ea;}\n#thera-module .theramap-root .table-view tr:last-child td {border-bottom: none;}\n#thera-module .theramap-root .hidden {display: none !important;}\n@media (max-width:1240px){#thera-module .theramap-root .hero {grid-template-columns: 1fr;}\n#thera-module .theramap-root .lane {grid-template-columns: 240px 160px 200px minmax(240px,1fr);}\n#thera-module .theramap-root .detail-header {grid-template-columns: 1fr;}\n#thera-module .theramap-root .detail-grid {grid-template-columns: 1fr 1fr;}\n}\n@media (max-width:980px){#thera-module .theramap-root .workspace {grid-template-columns: 1fr;}\n#thera-module .theramap-root .filters {position: static;}\n#thera-module .theramap-root .lane {grid-template-columns: 1fr;}\n#thera-module .theramap-root .family-cell,\n#thera-module .theramap-root .cell {border-right: 0; border-bottom: 1px solid #eee2ce;}\n#thera-module .theramap-root .cell:last-child {border-bottom: 0;}\n#thera-module .theramap-root .summary {grid-template-columns: repeat(2,minmax(0,1fr));}\n}\n@media (max-width:680px){#thera-module .theramap-root .page {padding: 22px 16px 36px;}\n#thera-module .theramap-root .legend-grid {grid-template-columns: 1fr;}\n#thera-module .theramap-root .summary {grid-template-columns: 1fr;}\n#thera-module .theramap-root .detail-grid {grid-template-columns: 1fr;}\n#thera-module .theramap-root h1 {font-size: 34px;}\n}\n#thera-sub-carte .repertoire-banner{min-height: 130px; background: linear-gradient(90deg, rgba(8,20,52,.72), rgba(8,20,52,.10)),\n linear-gradient(135deg, #0D47A1, #42A5F5); display: flex; align-items: center; color: #fff; padding: 24px 0; position: relative; overflow: hidden; border-radius: 14px; margin-bottom: 18px;}\n#thera-sub-carte .repertoire-banner::after{content: ''; position: absolute; right: 0; top: 0; bottom: 0; width: 340px; background: radial-gradient(circle at 75% 35%, rgba(255,255,255,.45), transparent 9%),\n radial-gradient(circle at 55% 60%, rgba(255,215,137,.35), transparent 8%),\n radial-gradient(circle at 90% 75%, rgba(66,165,245,.6), transparent 11%); opacity: .72; pointer-events: none;}\n#thera-sub-carte .repertoire-banner-inner{width: min(1180px, calc(100% - 48px)); margin: 0 auto; position: relative; z-index: 1;}\n#thera-sub-carte .repertoire-banner .eyebrow{color: #FFD180; text-transform: uppercase; letter-spacing: .08em; font-size: 13px; font-weight: 800; margin-bottom: 8px;}\n#thera-sub-carte .repertoire-banner h1{margin: 0; font-family: Georgia, \"Times New Roman\", serif; color: #ffffff; font-size: clamp(28px, 3vw, 44px); line-height: 1.05; letter-spacing: -.01em;}\n#thera-module .theramap-root {background: transparent; padding: 10px 0 30px; border-radius: 8px; margin-top: 6px;}\n#thera-module .theramap-root .page {max-width: 1180px; margin: 0 auto; padding: 22px 26px 30px;}\n#thera-module .theramap-root .hero {grid-template-columns: 1.05fr .95fr; gap: 22px; margin-bottom: 20px;}\n#thera-module .theramap-root .eyebrow {color: #a96c13; font-weight: 800;}\n#thera-module .theramap-root h1 {color: #081b35; font-size: clamp(28px, 3vw, 42px);}\n#thera-module .theramap-root .subtitle {color: #46536a; font-size: 14.5px;}\n#thera-module .theramap-root .legend {background: #ffffff; border: 1px solid #E0DDD7; color: #12223d; box-shadow: 0 4px 14px rgba(0,0,0,0.18);}\n#thera-module .theramap-root .legend-title {color: #0D1B2A;}\n#thera-module .theramap-root .legend-help {color: #5B7489;}\n#thera-module .theramap-root .summary {gap: 12px;}\n#thera-module .theramap-root .summary-card {background: #ffffff; border: 1px solid var(--gold); box-shadow: 0 4px 14px rgba(0,0,0,0.15);}\n#thera-module .theramap-root .workspace {gap: 18px; grid-template-columns: 240px 1fr;}\n@media (max-width: 980px){#thera-module .theramap-root .workspace {grid-template-columns: 1fr;}\n}\n#thera-module .theramap-root .panel.filters {background: #ffffff; border: 1px solid #E0DDD7; padding: 14px 14px 12px; box-shadow: 0 4px 14px rgba(0,0,0,0.15);}\n#thera-module .theramap-root .panel-title {font-size: 13px; color: #0D1B2A;}\n#thera-module .theramap-root .reset {color: #1565C0;}\n#thera-module .theramap-root .search {font-size: 13px; padding: 7px 10px;}\n#thera-module .theramap-root .filter-heading {color: #0D1B2A;}\n#thera-module .theramap-root .check-row {font-size: 12.5px;}\n#thera-module .theramap-root .help-card {background: #EAF3FA; border: 1px solid #B0CEE3; color: #0D1B2A; font-size: 12.5px;}\n#thera-module .theramap-root .help-card strong {color: #1565C0;}\n#thera-module .theramap-root .panel.main {background: #ffffff; border: 1px solid #E0DDD7; padding: 14px 14px 18px; box-shadow: 0 4px 14px rgba(0,0,0,0.15);}\n#thera-module .theramap-root .toolbar {font-size: 12.5px; color: #5B7489; padding-bottom: 8px; border-bottom: 1px solid #E0DDD7; margin-bottom: 10px;}\n#thera-module .theramap-root .mode-label {background: #EAF3FA; color: #1565C0; border-color: #B0CEE3;}\n#thera-module .theramap-root .lane {grid-template-columns: 230px 165px 200px minmax(360px, 1fr); gap: 0; min-height: 138px;}\n@media (max-width: 1100px){#thera-module .theramap-root .lane {grid-template-columns: 210px 145px 180px minmax(320px,1fr);}\n}\n@media (max-width: 900px){#thera-module .theramap-root .lane {grid-template-columns: 1fr;}\n#thera-module .theramap-root .therapy-list {grid-template-columns: 1fr;}\n}\n#thera-module .theramap-root .family-cell {padding: 14px 14px; min-width: 0;}\n#thera-module .theramap-root .family-title {font-size: 18px; word-wrap: break-word;}\n#thera-module .theramap-root .family-desc {font-size: 12px; line-height: 1.5;}\n#thera-module .theramap-root .cell {padding: 12px 14px; min-width: 0;}\n#thera-module .theramap-root .cell-label {font-size: 10.5px;}\n#thera-module .theramap-root .target-chip {font-size: 12px; padding: 4px 9px;}\n#thera-module .theramap-root .diagnostic {font-size: 12px; line-height: 1.45;}\n#thera-module .theramap-root .therapy-list {display: grid; grid-template-columns: repeat(2, minmax(170px, 1fr)); gap: 12px; align-items: start; min-width: 0;}\n#thera-module .theramap-root .therapy {padding: 10px 12px; min-width: 0; width: 100%; border-radius: 18px;}\n#thera-module .theramap-root .therapy:last-child:nth-child(odd) {grid-column: 1 / -1;}\n#thera-module .theramap-root .therapy-name {font-size: 12.5px; word-break: break-word; line-height: 1.35;}\n#thera-module .theramap-root .therapy-brand {font-size: 11px; word-break: break-word; white-space: normal; line-height: 1.4; margin-top: 3px;}\n#thera-module .theramap-root .status-pill {font-size: 10.5px; padding: 2px 7px; margin-top: 5px; display: inline-block;}\n#thera-module .theramap-root .detail {background: #ffffff; border: 1px solid #E0DDD7; margin-top: 16px; padding: 18px 20px;}\n#thera-module .theramap-root .detail h2 {color: #0D1B2A; font-size: 22px;}\n#thera-module .theramap-root .detail-subtitle {color: #5B7489; font-size: 13.5px;}\n#thera-module .theramap-root .explain {background: #EAF3FA; color: #0D1B2A; font-size: 12.5px; border: 1px solid #B0CEE3;}\n#thera-module .theramap-root .detail-section h3 {color: #0D1B2A; font-size: 14px;}\n#thera-module .theramap-root .badge {background: #EAF3FA; color: #1565C0;}\n#thera-module .theramap-root .warning {background: #FFF4E5; border-left-color: #FF6F00; color: #5B4631; font-size: 12px;}\n#thera-module .theramap-root .footer-note {color: #9EC2DC !important;}\n#thera-module .theramap-root .page {max-width: 1280px !important; width: 100% !important; margin: 0 auto !important; padding-left: 32px !important; padding-right: 32px !important;}\n#thera-module .theramap-root .workspace {grid-template-columns: 250px minmax(0, 1fr) !important; gap: 18px !important;}\n#thera-module .theramap-root .panel.main {overflow: visible !important; min-width: 0 !important;}\n#thera-module .theramap-root .lanes {min-width: 0 !important;}\n#thera-module .theramap-root .lane {overflow: visible !important; grid-template-columns: minmax(200px, 230px) minmax(135px, 165px) minmax(170px, 200px) minmax(340px, 1fr) !important; min-width: 0 !important;}\n#thera-module .theramap-root .cell {min-width: 0 !important;}\n#thera-module .theramap-root .therapy-list {grid-template-columns: repeat(2, minmax(145px, 1fr)) !important; gap: 12px !important; min-width: 0 !important;}\n#thera-module .theramap-root .therapy {min-width: 0 !important; max-width: 100% !important;}\n#thera-module .theramap-root .therapy-name,\n#thera-module .theramap-root .therapy-brand {overflow-wrap: anywhere !important; word-break: normal !important;}\n@media (max-width: 1180px){#thera-module .theramap-root .page {padding-left: 20px !important; padding-right: 20px !important;}\n#thera-module .theramap-root .workspace {grid-template-columns: 230px minmax(0, 1fr) !important; gap: 14px !important;}\n#thera-module .theramap-root .lane {grid-template-columns: minmax(180px, 210px) minmax(120px, 145px) minmax(145px, 175px) minmax(285px, 1fr) !important;}\n#thera-module .theramap-root .therapy-list {grid-template-columns: repeat(2, minmax(125px, 1fr)) !important; gap: 10px !important;}\n#thera-module .theramap-root .therapy-name {font-size: 12px !important;}\n#thera-module .theramap-root .therapy-brand {font-size: 10.5px !important;}\n#thera-module .theramap-root .family-title {font-size: 17px !important;}\n}\n@media (max-width: 980px){#thera-module .theramap-root .workspace {grid-template-columns: 1fr !important;}\n#thera-module .theramap-root .filters {position: static !important;}\n#thera-module .theramap-root .lane {grid-template-columns: 1fr !important; overflow: hidden !important;}\n#thera-module .theramap-root .therapy-list {grid-template-columns: repeat(2, minmax(150px, 1fr)) !important;}\n}\n@media (max-width: 620px){#thera-module .theramap-root .therapy-list {grid-template-columns: 1fr !important;}\n}\n\n\n#page-theranostique #thera-module .thera-subtabs{width: 100% !important; margin-left: 0 !important; margin-right: 0 !important;}\n#page-theranostique #thera-module .theramap-root .page{margin-left: auto !important; margin-right: auto !important;}\n\n\n\n\n\n\n\n\n"}