[{"id":"lutathera","family":"net","status":"standard","name":"¹⁷⁷Lu-oxodotreotide","commercial":"Lutathera®","diagnostic":"PET ⁶⁸Ga-DOTA-SSA selon disponibilité","indications":["GEP-NET bien différenciées SSTR+","Maladie non résécable ou métastatique, progressive, selon indication européenne"],"notes":"Agent standard EMA pour les GEP-NET SSTR+. Garder les extensions d’indication séparées.","tags":["AMM EMA","PRRT","SSTR"]},{"id":"y90-dotatoc","family":"net","status":"academic","name":"⁹⁰Y-DOTATOC / ⁹⁰Y-DOTATATE","commercial":"—","diagnostic":"PET ⁶⁸Ga-DOTA-SSA","indications":["Approches historiques/académiques SSTR+"],"notes":"Accès et standardisation variables ; ne pas présenter comme équivalent réglementaire à Lutathera®.","tags":["Accès variable","SSTR"]},{"id":"cu67-sartate","family":"net","status":"research","name":"⁶⁷Cu-SARTATE","commercial":"—","diagnostic":"⁶⁴Cu-DOTATATE / ⁶⁴Cu-SARTATE selon protocole","indications":["Recherche clinique SSTR+"],"notes":"Recherche ; pas standard clinique européen de routine.","tags":["Recherche","Cu-67"]},{"id":"tb161-sstr","family":"net","status":"research","name":"¹⁶¹Tb-DOTATOC / ¹⁶¹Tb-DOTATATE","commercial":"—","diagnostic":"Vecteurs SSTR analogues selon protocole","indications":["Recherche SSTR+"],"notes":"Recherche ; disponibilité limitée.","tags":["Recherche","Tb-161"]},{"id":"pluvicto","family":"prostate","status":"standard","name":"¹⁷⁷Lu-vipivotide tetraxetan","commercial":"Pluvicto®","diagnostic":"PET PSMA : ⁶⁸Ga-PSMA-11 ou ¹⁸F-PSMA selon disponibilité","indications":["mCRPC PSMA+","Après ARPI et taxane selon indication européenne actuelle"],"notes":"AMM EMA. L’extension pré-taxane européenne n’est pas à présenter comme validée après le retrait de variation d’avril 2026.","tags":["AMM EMA","PSMA","mCRPC"]},{"id":"psma-it","family":"prostate","status":"academic","name":"¹⁷⁷Lu-PSMA-I&T","commercial":"—","diagnostic":"PET PSMA","indications":["Usage académique, essais ou accès local PSMA+"],"notes":"Vecteur PSMA différent ; statut réglementaire variable.","tags":["Accès variable","PSMA"]},{"id":"ac225-psma","family":"prostate","status":"research","name":"²²⁵Ac-PSMA-617","commercial":"—","diagnostic":"PET PSMA","indications":["Approches alpha-thérapie en centres experts ou essais"],"notes":"Recherche/compassionnel ; toxicité et disponibilité du ²²⁵Ac à considérer.","tags":["Alpha","Recherche"]},{"id":"tb161-psma","family":"prostate","status":"research","name":"¹⁶¹Tb-PSMA","commercial":"—","diagnostic":"PET PSMA","indications":["Recherche PSMA+"],"notes":"Recherche ; pas équivalent réglementaire à Pluvicto®.","tags":["Recherche","Tb-161"]},{"id":"lu177-fapi","family":"stroma","status":"research","name":"¹⁷⁷Lu-FAPI","commercial":"—","diagnostic":"PET FAPI","indications":["Tumeurs solides riches en FAP selon essais"],"notes":"Pas d’AMM EMA de routine ; recherche ou accès expert.","tags":["FAP","Recherche"]},{"id":"y90-fapi","family":"stroma","status":"research","name":"⁹⁰Y-FAPI","commercial":"—","diagnostic":"PET FAPI","indications":["Recherche précoce"],"notes":"Données limitées.","tags":["Recherche"]},{"id":"ac225-fapi","family":"stroma","status":"research","name":"²²⁵Ac-FAPI","commercial":"—","diagnostic":"PET FAPI","indications":["Recherche alpha-thérapie FAP"],"notes":"À présenter comme expérimental.","tags":["Alpha","Recherche"]},{"id":"lu177-rm2","family":"grpr","status":"research","name":"¹⁷⁷Lu-RM2","commercial":"—","diagnostic":"PET ⁶⁸Ga-RM2 / ⁶⁸Ga-NeoBOMB1","indications":["Tumeurs GRPR+ selon essais"],"notes":"Études précoces ; statut recherche.","tags":["GRPR","Recherche"]},{"id":"i131-mibg","family":"mibg","status":"historic","name":"¹³¹I-iobenguane / ¹³¹I-MIBG","commercial":"noms nationaux variables","diagnostic":"¹²³I-MIBG SPECT","indications":["PPGL MIBG+","Neuroblastome MIBG+ selon protocoles"],"notes":"Disponibilité et cadre réglementaire variables selon pays.","tags":["Historique","MIBG"]},{"id":"i131-nai","family":"thyroid","status":"historic","name":"¹³¹I-iodure de sodium","commercial":"noms nationaux variables","diagnostic":"¹²³I ou ¹³¹I diagnostique selon indication","indications":["Hyperthyroïdie","Cancer thyroïdien différencié captant l’iode"],"notes":"Traitement historique et standard, avec produits et libellés nationaux variables.","tags":["Iode","NIS"]},{"id":"pentixather","family":"hematology","status":"research","name":"¹⁷⁷Lu-pentixather / ⁹⁰Y-pentixather","commercial":"—","diagnostic":"PET ⁶⁸Ga-pentixafor","indications":["Hématologie et tumeurs CXCR4+ en programmes spécialisés"],"notes":"Recherche / académique ; pas standard de routine.","tags":["CXCR4","Recherche"]},{"id":"xofigo","family":"bone","status":"standard","name":"²²³Ra-dichloride","commercial":"Xofigo®","diagnostic":"Scintigraphie osseuse / imagerie osseuse selon contexte","indications":["mCRPC avec métastases osseuses symptomatiques","Sans métastases viscérales connues, selon indication européenne"],"notes":"Alpha-émetteur à tropisme osseux ; pas un couple ligand-récepteur PET strict.","tags":["AMM EMA","Alpha","Os"]},{"id":"sir-spheres","family":"liver","status":"standard","name":"⁹⁰Y resin microspheres","commercial":"SIR-Spheres®","diagnostic":"⁹⁹ᵐTc-MAA SPECT/CT + imagerie post-thérapie","indications":["HCC non résécable","Métastases hépatiques sélectionnées selon indication locale/CE"],"notes":"Dispositif de radioembolisation ; logique procédurale et dosimétrique.","tags":["CE","Foie","Radioembolisation"]},{"id":"therasphere","family":"liver","status":"standard","name":"⁹⁰Y glass microspheres","commercial":"TheraSphere™","diagnostic":"⁹⁹ᵐTc-MAA SPECT/CT + imagerie post-thérapie","indications":["Malignités hépatiques sélectionnées"],"notes":"Dispositif CE pour traitement de néoplasies hépatiques ; indications exactes selon juridiction.","tags":["CE","Foie","Radioembolisation"]},{"id":"quirem","family":"liver","status":"standard","name":"¹⁶⁶Ho microspheres","commercial":"QuiremSpheres®","diagnostic":"⁹⁹ᵐTc-MAA ou scout holmium selon protocole + imagerie holmium","indications":["Tumeurs hépatiques sélectionnées"],"notes":"Microsphères holmium-166 CE ; disponibilité et protocole selon centre/pays.","tags":["CE","Ho-166","Foie"]}]